Reactome | TNF signaling

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TNF signaling Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222375
displayName	TNF signaling
eventOf	[Pathway:R-RNO-73887] Death Receptor Signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:261164] tumor necrosis factor-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-3371385] TNF-? is cleaved by ADAM17 (TACE) - Rattus norvegicus [Reaction:R-RNO-9714924] TNF-alpha inhibitors bind to soluble TNF trimer - Rattus norvegicus [Reaction:R-RNO-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer - Rattus norvegicus [Reaction:R-RNO-3371353] Soluble TNF-? binds TNFR1 - Rattus norvegicus [Reaction:R-RNO-83660] Membrane-anchored TNF-? binds TNFR1 - Rattus norvegicus [Reaction:R-RNO-83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - Rattus norvegicus [Pathway:R-RNO-5357956] TNFR1-induced NF-kappa-B signaling pathway - Rattus norvegicus [Pathway:R-RNO-5357786] TNFR1-induced proapoptotic signaling - Rattus norvegicus [Pathway:R-RNO-5626978] TNFR1-mediated ceramide production - Rattus norvegicus [Pathway:R-RNO-5357905] Regulation of TNFR1 signaling - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-75893] TNF signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	TNF signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-75893
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-RNO-140534] Caspase activation via Death Receptors in the presence of ligand [Pathway:R-RNO-5357769] Caspase activation via extrinsic apoptotic signalling pathway
(hasEvent)	[Pathway:R-RNO-73887] Death Receptor Signaling
(inferredTo)	[Pathway:R-HSA-75893] TNF signaling

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