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Entries
TNFR1-mediated ceramide production
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authored
[InstanceEdit:5692499] Shamovsky, Veronica, 2015-05-12
created
[InstanceEdit:5626975] Shamovsky, V, 2014-10-14
crossReference
[DatabaseIdentifier:12819459] BioModels Database:BIOMD0000000407
[DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId
5626978
displayName
TNFR1-mediated ceramide production
edited
[InstanceEdit:5675041] Shamovsky, V, 2015-02-15
eventOf
[Pathway:R-HSA-75893] TNF signaling - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:1221467] positive regulation of ceramide biosynthetic process
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-5626988] TNF-?:TNFR1 binds NSMAF - Homo sapiens
[Reaction:R-HSA-5626982] TNF-?:TNFR1:NSMAF binds RACK1 - Homo sapiens
[Reaction:R-HSA-5626981] TNF-?:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3 - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2022-09-14
literatureReference
[LiteratureReference:5657786] A novel cytoplasmic domain of the p55 tumor necrosis factor receptor initiates the neutral sphingomyelinase pathway
maxDepth
2
modified
[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name
TNFR1-mediated ceramide production
orthologousEvent
[Pathway:R-GGA-5626978] TNFR1-mediated ceramide production - Gallus gallus
[Pathway:R-XTR-5626978] TNFR1-mediated ceramide production - Xenopus tropicalis
[Pathway:R-DRE-5626978] TNFR1-mediated ceramide production - Danio rerio
[Pathway:R-SSC-5626978] TNFR1-mediated ceramide production - Sus scrofa
[Pathway:R-BTA-5626978] TNFR1-mediated ceramide production - Bos taurus
[Pathway:R-CFA-5626978] TNFR1-mediated ceramide production - Canis familiaris
[Pathway:R-RNO-5626978] TNFR1-mediated ceramide production - Rattus norvegicus
[Pathway:R-MMU-5626978] TNFR1-mediated ceramide production - Mus musculus
releaseDate
2015-09-22
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5683087] Gillespie, Marc E, 2015-03-11
[InstanceEdit:6792551] Wajant, Harald, 2015-08-25
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5626978
summation
[Summation:5657737] TNF-alpha activates sphingomyelinase (SMASE) proteins to cat...
updateTrackers
[UpdateTracker:9846974] Update Tracker - [Pathway:5626978] TNFR1-mediated ceramide production - v82:[updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9846974] Update Tracker - [Pathway:5626978] TNFR1-mediated ceramide production - v82:[updateContainedRLE]
(hasEvent)
[Pathway:R-HSA-75893] TNF signaling
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