Reactome | TNF signaling

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TNF signaling Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10730646
displayName	TNF signaling
eventOf	[Pathway:R-XTR-73887] Death Receptor Signaling - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:261164] tumor necrosis factor-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-XTR-3371385] TNF-? is cleaved by ADAM17 (TACE) - Xenopus tropicalis [Reaction:R-XTR-9714924] TNF-alpha inhibitors bind to soluble TNF trimer - Xenopus tropicalis [Reaction:R-XTR-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer - Xenopus tropicalis [Pathway:R-XTR-5357956] TNFR1-induced NF-kappa-B signaling pathway - Xenopus tropicalis [Pathway:R-XTR-5626978] TNFR1-mediated ceramide production - Xenopus tropicalis [Pathway:R-XTR-5357905] Regulation of TNFR1 signaling - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-75893] TNF signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	TNF signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-75893
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-73887] Death Receptor Signaling
(inferredTo)	[Pathway:R-HSA-75893] TNF signaling
(hasEncapsulatedEvent)	[Pathway:R-XTR-5357769] Caspase activation via extrinsic apoptotic signalling pathway

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