Reactome | Conversion of malonyl-CoA and acetyl-CoA to palmitate

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Conversion of malonyl-CoA and acetyl-CoA to palmitate Show undefined attributes

authored	[InstanceEdit:77382] Joshi-Tope, G, 2003-10-23 17:11:00
catalystActivity	[CatalystActivity:539119] fatty acid synthase activity of FASN dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:75111] Gopinathrao, G, 2003-09-07 15:00:00
crossReference	[DatabaseIdentifier:9865850] RHEA:14994
dbId	75872
displayName	Conversion of malonyl-CoA and acetyl-CoA to palmitate
eventOf	[Pathway:R-HSA-75105] Fatty acyl-CoA biosynthesis - Homo sapiens
figure	[Figure:77457] /figures/Butyrl_Palmitoyl.jpg
input	[SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] 14 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 7 × [SimpleEntity:R-ALL-29508] Mal-CoA [cytosol] 14 × [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:200074] Human fatty acid synthase: properties and molecular cloning [LiteratureReference:76569] Structural and functional organization of the animal fatty acid synthase.
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Conversion of malonyl-CoA and acetyl-CoA to palmitate acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+) acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O
orthologousEvent	[Reaction:R-DDI-75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate - Dictyostelium discoideum [Reaction:R-CEL-75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate - Caenorhabditis elegans [Reaction:R-DME-75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate - Drosophila melanogaster [Reaction:R-GGA-75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate - Gallus gallus [Reaction:R-XTR-75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate - Xenopus tropicalis [Reaction:R-DRE-75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate - Danio rerio [Reaction:R-SSC-75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate - Sus scrofa [Reaction:R-BTA-75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate - Bos taurus [Reaction:R-CFA-75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate - Canis familiaris [Reaction:R-RNO-75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate - Rattus norvegicus [Reaction:R-MMU-75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate - Mus musculus
output	7 × [SimpleEntity:R-ALL-113528] CO2 [cytosol] 8 × [SimpleEntity:R-ALL-76194] CoA-SH [cytosol] 6 × [SimpleEntity:R-ALL-29356] H2O [cytosol] 14 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-3632881] PALM [cytosol]
precedingEvent	[Reaction:R-HSA-200555] Formation of Malonyl-CoA from Acetyl-CoA (liver) - Homo sapiens [Reaction:R-HSA-163756] Formation of fatty acid synthase (FAS) dimer - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-75872
summation	[Summation:77381] Cytosolic fatty acid synthase (FAS) complex catalyzes the re...
updateTrackers	[UpdateTracker:9911031] Update Tracker - [Reaction:75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate - v89:[addLiteratureReference, modifyText] [UpdateTracker:9785110] Update Tracker - [Reaction:75872] acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O - v52:[add_removeOutput] [UpdateTracker:9790524] Update Tracker - [Reaction:75872] acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O - v33:[add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)

[UpdateTracker:9911031] Update Tracker - [Reaction:75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate - v89:[addLiteratureReference, modifyText]
[UpdateTracker:9785110] Update Tracker - [Reaction:75872] acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O - v52:[add_removeOutput]
[UpdateTracker:9790524] Update Tracker - [Reaction:75872] acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O - v33:[add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText]

(hasEvent)

[Pathway:R-HSA-75105] Fatty acyl-CoA biosynthesis