Reactome | acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O

Schema > Reaction > Entries

acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O Show undefined attributes

catalystActivity	[CatalystActivity:10565379] fatty acid synthase activity of FASN dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
dbId	10565381
displayName	acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O
eventOf	[Pathway:R-GGA-75105] Fatty acyl-CoA biosynthesis - Gallus gallus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-75872] acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O - Homo sapiens
input	[SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] 14 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 7 × [SimpleEntity:R-ALL-29508] Mal-CoA [cytosol] 14 × [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
name	acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O Conversion of malonyl-CoA and acetyl-CoA to palmitate
output	7 × [SimpleEntity:R-ALL-113528] CO2 [cytosol] 8 × [SimpleEntity:R-ALL-76194] CoA-SH [cytosol] 6 × [SimpleEntity:R-ALL-29356] H2O [cytosol] 14 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-3632881] PALM [cytosol]
precedingEvent	[Reaction:R-GGA-200555] acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate - Gallus gallus [Reaction:R-GGA-163756] Formation of fatty acid synthase (FAS) dimer - Gallus gallus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-75872
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-75105] Fatty acyl-CoA biosynthesis
(inferredTo)	[Reaction:R-HSA-75872] acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O

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