Reactome | Fatty acyl-CoA biosynthesis

Schema > Pathway > Entries

Fatty acyl-CoA biosynthesis Show undefined attributes

authored	[InstanceEdit:76206] Gopinathrao, G, 2003-10-03 00:00:00
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:75111] Gopinathrao, G, 2003-09-07 15:00:00
dbId	75105
deleted	[Deleted:539128] Deletion of instance: 75853 [Deleted:539126] Deletion of instance: 75854 [Deleted:539129] Deletion of instance: 75870 [Deleted:539133] Deletion of instance: 75865 [Deleted:539125] Deletion of instance: 75860 [Deleted:539134] Deletion of instance: 75852 [Deleted:539135] Deletion of instance: 75867 [Deleted:539132] Deletion of instance: 75863 [Deleted:539130] Deletion of instance: 75855 [Deleted:539136] Deletion of instance: 75113 [Deleted:539131] Deletion of instance: 75107 [Deleted:539123] Deletion of instance: 75857
displayName	Fatty acyl-CoA biosynthesis
doi	10.3180/R-HSA-75105.11
edited	[InstanceEdit:76206] Gopinathrao, G, 2003-10-03 00:00:00
eventOf	[Pathway:R-HSA-8978868] Fatty acid metabolism - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:78809] fatty-acyl-CoA biosynthetic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-75848] ACLY tetramer transforms CIT to Ac-CoA - Homo sapiens [Reaction:R-HSA-9734535] SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA - Homo sapiens [Reaction:R-HSA-9734540] ACLY tetramer binds ETC-1002-CoA - Homo sapiens [Reaction:R-HSA-200555] Formation of Malonyl-CoA from Acetyl-CoA (liver) - Homo sapiens [Reaction:R-HSA-163756] Formation of fatty acid synthase (FAS) dimer - Homo sapiens [Reaction:R-HSA-75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate - Homo sapiens [Reaction:R-HSA-5655955] OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer - Homo sapiens [Pathway:R-HSA-75876] Synthesis of very long-chain fatty acyl-CoAs - Homo sapiens [Reaction:R-HSA-5690565] SCD desaturates ST-CoA to OLE-CoA - Homo sapiens [Reaction:R-HSA-8847579] SCD5 desaturates ST-CoA to OLE-CoA - Homo sapiens [Reaction:R-HSA-5690517] PPT1 hydrolyses palmitoylated proteins - Homo sapiens [Reaction:R-HSA-5690046] PPT2 hydrolyses PALMCoA to PALM - Homo sapiens [Reaction:R-HSA-8862152] 2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP - Homo sapiens [Reaction:R-HSA-8957389] RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:8979272] Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering
maxDepth	3
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Fatty acyl-CoA biosynthesis
orthologousEvent	[Pathway:R-MMU-75105] Fatty acyl-CoA biosynthesis - Mus musculus [Pathway:R-RNO-75105] Fatty acyl-CoA biosynthesis - Rattus norvegicus [Pathway:R-CFA-75105] Fatty acyl-CoA biosynthesis - Canis familiaris [Pathway:R-BTA-75105] Fatty acyl-CoA biosynthesis - Bos taurus [Pathway:R-SSC-75105] Fatty acyl-CoA biosynthesis - Sus scrofa [Pathway:R-DRE-75105] Fatty acyl-CoA biosynthesis - Danio rerio [Pathway:R-XTR-75105] Fatty acyl-CoA biosynthesis - Xenopus tropicalis [Pathway:R-GGA-75105] Fatty acyl-CoA biosynthesis - Gallus gallus [Pathway:R-DME-75105] Fatty acyl-CoA biosynthesis - Drosophila melanogaster [Pathway:R-CEL-75105] Fatty acyl-CoA biosynthesis - Caenorhabditis elegans [Pathway:R-DDI-75105] Fatty acyl-CoA biosynthesis - Dictyostelium discoideum [Pathway:R-SPO-75105] Fatty acyl-CoA biosynthesis - Schizosaccharomyces pombe [Pathway:R-SCE-75105] Fatty acyl-CoA biosynthesis - Saccharomyces cerevisiae [Pathway:R-PFA-75105] Fatty acyl-CoA biosynthesis - Plasmodium falciparum
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9863300] Matthews, Lisa, 2024-02-28
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-75105
summation	[Summation:76207] Fatty acyl-CoA biosynthesis involves following steps: -P...
updateTrackers	[UpdateTracker:9782303] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v59:[updateContainedRLE] [UpdateTracker:9846904] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v83:[updateContainedPathway] [UpdateTracker:9780902] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v61:[updateContainedRLE] [UpdateTracker:9910969] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v89:[addHasEvent, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9790669] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v33:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9846761] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v84:[updateContainedRLE] [UpdateTracker:9783318] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v57:[addHasEvent] [UpdateTracker:9783709] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v56:[addHasEvent, updateContainedRLE] [UpdateTracker:9781945] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v60:[addLiteratureReference, add_removeHasEvent, updateContainedPathway, updateContainedRLE] [UpdateTracker:9784412] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v54:[addHasEvent, updateContainedPathway] [UpdateTracker:9774835] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v81:[addHasEvent] [UpdateTracker:9785038] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v52:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9784674] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v53:[updateIndirectRLE] [UpdateTracker:9864241] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v88:[removeHasEvent, updateContainedRLE] [UpdateTracker:9782853] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v58:[updateContainedPathway, updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-8978868] Fatty acid metabolism
(replacementInstances)	[Deleted:539128] Deletion of instance: 75853 [Deleted:539126] Deletion of instance: 75854 [Deleted:539129] Deletion of instance: 75870 [Deleted:539133] Deletion of instance: 75865 [Deleted:539125] Deletion of instance: 75860 [Deleted:539134] Deletion of instance: 75852 [Deleted:539135] Deletion of instance: 75867 [Deleted:539132] Deletion of instance: 75863 [Deleted:539130] Deletion of instance: 75855 [Deleted:539136] Deletion of instance: 75113 [Deleted:539131] Deletion of instance: 75107 [Deleted:539123] Deletion of instance: 75857
(updatedInstance)	[UpdateTracker:9782303] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v59:[updateContainedRLE] [UpdateTracker:9846904] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v83:[updateContainedPathway] [UpdateTracker:9780902] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v61:[updateContainedRLE] [UpdateTracker:9910969] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v89:[addHasEvent, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9790669] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v33:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9846761] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v84:[updateContainedRLE] [UpdateTracker:9783318] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v57:[addHasEvent] [UpdateTracker:9783709] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v56:[addHasEvent, updateContainedRLE] [UpdateTracker:9781945] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v60:[addLiteratureReference, add_removeHasEvent, updateContainedPathway, updateContainedRLE] [UpdateTracker:9784412] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v54:[addHasEvent, updateContainedPathway] [UpdateTracker:9774835] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v81:[addHasEvent] [UpdateTracker:9785038] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v52:[addHasEvent, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9784674] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v53:[updateIndirectRLE] [UpdateTracker:9864241] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v88:[removeHasEvent, updateContainedRLE] [UpdateTracker:9782853] Update Tracker - [Pathway:75105] Fatty acyl-CoA biosynthesis - v58:[updateContainedPathway, updateContainedRLE]

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