Reactome | Fatty acyl-CoA biosynthesis

Schema > Pathway > Entries

Fatty acyl-CoA biosynthesis Show undefined attributes

authored	[InstanceEdit:76206] Gopinathrao, G, 2003-10-03 00:00:00
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:75111] Gopinathrao, G, 2003-09-07 15:00:00
dbId	75105
displayName	Fatty acyl-CoA biosynthesis
edited	[InstanceEdit:76206] Gopinathrao, G, 2003-10-03 00:00:00
eventOf	[Pathway:R-HSA-8978868] Fatty acid metabolism - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:78809] fatty-acyl-CoA biosynthetic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-75848] ACLY tetramer transforms CIT to Ac-CoA - Homo sapiens [Reaction:R-HSA-9734535] SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA - Homo sapiens [Reaction:R-HSA-200555] acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate - Homo sapiens [Reaction:R-HSA-163756] Formation of fatty acid synthase (FAS) dimer - Homo sapiens [Reaction:R-HSA-75872] acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O - Homo sapiens [Reaction:R-HSA-5655955] OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer - Homo sapiens [Pathway:R-HSA-75876] Synthesis of very long-chain fatty acyl-CoAs - Homo sapiens [Reaction:R-HSA-5690565] SCD desaturates ST-CoA to OLE-CoA - Homo sapiens [Reaction:R-HSA-8847579] SCD5 desaturates ST-CoA to OLE-CoA - Homo sapiens [Reaction:R-HSA-5690517] PPT1 hydrolyses palmitoylated proteins - Homo sapiens [Reaction:R-HSA-5690046] PPT2 hydrolyses PALMCoA to PALM - Homo sapiens [Reaction:R-HSA-8862152] 2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP - Homo sapiens [Reaction:R-HSA-8957389] RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8979272] Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	Fatty acyl-CoA biosynthesis
orthologousEvent	[Pathway:R-MMU-75105] Fatty acyl-CoA biosynthesis - Mus musculus [Pathway:R-PFA-75105] Fatty acyl-CoA biosynthesis - Plasmodium falciparum [Pathway:R-SCE-75105] Fatty acyl-CoA biosynthesis - Saccharomyces cerevisiae [Pathway:R-SPO-75105] Fatty acyl-CoA biosynthesis - Schizosaccharomyces pombe [Pathway:R-DDI-75105] Fatty acyl-CoA biosynthesis - Dictyostelium discoideum [Pathway:R-CEL-75105] Fatty acyl-CoA biosynthesis - Caenorhabditis elegans [Pathway:R-DME-75105] Fatty acyl-CoA biosynthesis - Drosophila melanogaster [Pathway:R-GGA-75105] Fatty acyl-CoA biosynthesis - Gallus gallus [Pathway:R-XTR-75105] Fatty acyl-CoA biosynthesis - Xenopus tropicalis [Pathway:R-DRE-75105] Fatty acyl-CoA biosynthesis - Danio rerio [Pathway:R-SSC-75105] Fatty acyl-CoA biosynthesis - Sus scrofa [Pathway:R-RNO-75105] Fatty acyl-CoA biosynthesis - Rattus norvegicus [Pathway:R-BTA-75105] Fatty acyl-CoA biosynthesis - Bos taurus [Pathway:R-CFA-75105] Fatty acyl-CoA biosynthesis - Canis familiaris
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9863300] Matthews, Lisa, 2024-02-28
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-75105
summation	[Summation:76207] Fatty acyl-CoA biosynthesis involves following steps: -P...

Referrals

(hasEvent)	[Pathway:R-HSA-8978868] Fatty acid metabolism
(hasEncapsulatedEvent)	[Pathway:R-HSA-425393] Transport of inorganic cations/anions and amino acids/oligopeptides

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