Reactome | Conversion of malonyl-CoA and acetyl-CoA to palmitate

Schema > Reaction > Entries

Conversion of malonyl-CoA and acetyl-CoA to palmitate Show undefined attributes

catalystActivity	[CatalystActivity:10338541] fatty acid synthase activity of FASN dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10338543
displayName	Conversion of malonyl-CoA and acetyl-CoA to palmitate
eventOf	[Pathway:R-BTA-75105] Fatty acyl-CoA biosynthesis - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate - Homo sapiens
input	[SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] 14 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 7 × [SimpleEntity:R-ALL-29508] Mal-CoA [cytosol] 14 × [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Conversion of malonyl-CoA and acetyl-CoA to palmitate acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+) acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O
output	7 × [SimpleEntity:R-ALL-113528] CO2 [cytosol] 8 × [SimpleEntity:R-ALL-76194] CoA-SH [cytosol] 6 × [SimpleEntity:R-ALL-29356] H2O [cytosol] 14 × [SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-3632881] PALM [cytosol]
precedingEvent	[Reaction:R-BTA-200555] Formation of Malonyl-CoA from Acetyl-CoA (liver) - Bos taurus [Reaction:R-BTA-163756] Formation of fatty acid synthase (FAS) dimer - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-75872
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-75105] Fatty acyl-CoA biosynthesis
(inferredTo)	[Reaction:R-HSA-75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate

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