Reactome | SCD5 desaturates ST-CoA to OLE-CoA

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SCD5 desaturates ST-CoA to OLE-CoA Show undefined attributes

authored	[InstanceEdit:8847577] D'Eustachio, Peter, 2015-11-30
catalystActivity	[CatalystActivity:8847576] stearoyl-CoA 9-desaturase activity of SCD5 dimer [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9643204] stearoyl-CoA 9-desaturase activity of SCD5 dimer [endoplasmic reticulum membrane] Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:8847577] D'Eustachio, Peter, 2015-11-30
crossReference	[DatabaseIdentifier:9865944] RHEA:19722
dbId	8847579
displayName	SCD5 desaturates ST-CoA to OLE-CoA
edited	[InstanceEdit:8847577] D'Eustachio, Peter, 2015-11-30
eventOf	[Pathway:R-HSA-75105] Fatty acyl-CoA biosynthesis - Homo sapiens
input	2 × [SimpleEntity:R-ALL-4085415] Fe(2+)Cb5 [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol] [SimpleEntity:R-ALL-428139] ST-CoA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8847582] Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates [LiteratureReference:8847578] Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SCD5 desaturates ST-CoA to OLE-CoA 2 Fe(II)-(cytochrome b5) + 2 H(+) + O2 + octadecanoyl-CoA => (9Z)-octadecenoyl-CoA + 2 Fe(III)-(cytochrome b5) + 2 H2O
orthologousEvent	[Reaction:R-PFA-8847579] SCD5 desaturates ST-CoA to OLE-CoA - Plasmodium falciparum [Reaction:R-SCE-8847579] SCD5 desaturates ST-CoA to OLE-CoA - Saccharomyces cerevisiae [Reaction:R-SPO-8847579] SCD5 desaturates ST-CoA to OLE-CoA - Schizosaccharomyces pombe [Reaction:R-DDI-8847579] SCD5 desaturates ST-CoA to OLE-CoA - Dictyostelium discoideum [Reaction:R-CEL-8847579] SCD5 desaturates ST-CoA to OLE-CoA - Caenorhabditis elegans [Reaction:R-DME-8847579] SCD5 desaturates ST-CoA to OLE-CoA - Drosophila melanogaster [Reaction:R-GGA-8847579] SCD5 desaturates ST-CoA to OLE-CoA - Gallus gallus [Reaction:R-SSC-8847579] SCD5 desaturates ST-CoA to OLE-CoA - Sus scrofa [Reaction:R-BTA-8847579] SCD5 desaturates ST-CoA to OLE-CoA - Bos taurus [Reaction:R-CFA-8847579] SCD5 desaturates ST-CoA to OLE-CoA - Canis familiaris
output	2 × [SimpleEntity:R-ALL-4085425] Fe(3+)Cb5 [cytosol] 2 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-5690558] OLE-CoA [cytosol]
precedingEvent	[Reaction:R-HSA-548831] TECR,TECRL dehydrogenate TOD-CoA to ST-CoA - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8854946] Jassal, Bijay, 2016-01-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8847579
summation	[Summation:8847585] Stearoyl-CoA desaturase 5 (SCD5, also known as acyl-CoA desa...

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[Pathway:R-HSA-75105] Fatty acyl-CoA biosynthesis

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