Reactome | PPT2 hydrolyses PALMCoA to PALM

Schema > Reaction > Entries

PPT2 hydrolyses PALMCoA to PALM Show undefined attributes

authored	[InstanceEdit:5690061] Jassal, Bijay, 2015-04-27
catalystActivity	[CatalystActivity:5690062] palmitoyl hydrolase activity of PPT2 [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:5690061] Jassal, Bijay, 2015-04-27
crossReference	[DatabaseIdentifier:12668392] RHEA:16646
dbId	5690046
displayName	PPT2 hydrolyses PALMCoA to PALM
edited	[InstanceEdit:5690061] Jassal, Bijay, 2015-04-27
eventOf	[Pathway:R-HSA-75105] Fatty acyl-CoA biosynthesis - Homo sapiens
input	[SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen] [SimpleEntity:R-ALL-5690537] PALM-CoA [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5690372] New players on the metabolic stage: How do you like Them Acots? [LiteratureReference:5690404] The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism [LiteratureReference:5690397] Functional and structural properties of mammalian acyl-coenzyme A thioesterases [LiteratureReference:5690545] Molecular cloning and expression of palmitoyl-protein thioesterase 2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase with a distinct substrate specificity
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	PPT2 hydrolyses PALMCoA to PALM H2O + hexadecanoyl-CoA => CoA + H(+) + hexadecanoate
orthologousEvent	[Reaction:R-DDI-5690046] PPT2 hydrolyses PALMCoA to PALM - Dictyostelium discoideum [Reaction:R-DME-5690046] PPT2 hydrolyses PALMCoA to PALM - Drosophila melanogaster [Reaction:R-XTR-5690046] PPT2 hydrolyses PALMCoA to PALM - Xenopus tropicalis [Reaction:R-DRE-5690046] PPT2 hydrolyses PALMCoA to PALM - Danio rerio [Reaction:R-SSC-5690046] PPT2 hydrolyses PALMCoA to PALM - Sus scrofa [Reaction:R-BTA-5690046] PPT2 hydrolyses PALMCoA to PALM - Bos taurus [Reaction:R-CFA-5690046] PPT2 hydrolyses PALMCoA to PALM - Canis familiaris [Reaction:R-RNO-5690046] PPT2 hydrolyses PALMCoA to PALM - Rattus norvegicus [Reaction:R-MMU-5690046] PPT2 hydrolyses PALMCoA to PALM - Mus musculus
output	[SimpleEntity:R-ALL-1678675] CoA-SH [lysosomal lumen] [SimpleEntity:R-ALL-428040] H+ [lysosomal lumen] [SimpleEntity:R-ALL-5690516] PALM [lysosomal lumen]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26 [InstanceEdit:9907581] Hill, David P, 2024-04-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5690046
summation	[Summation:5690518] The maintenance/regulation of cellular levels of free fatty ...
updateTrackers	[UpdateTracker:9910990] Update Tracker - [Reaction:5690046] PPT2 hydrolyses PALMCoA to PALM - v89:[addOutput]

Referrals

(updatedInstance)	[UpdateTracker:9910990] Update Tracker - [Reaction:5690046] PPT2 hydrolyses PALMCoA to PALM - v89:[addOutput]
(hasEvent)	[Pathway:R-HSA-75105] Fatty acyl-CoA biosynthesis