Inactive p21ras:GDP is anchored to the plasma membrane by a farnesyl residue. Insulin stimulation results in phosphorylation of IRS1/2 on tyrosine residues. GRB2 binds the phosphotyrosines via its SH2 domain. As IRS is phosphorylated by the insulin receptor near to the plasma membrane, the GRB2:SOS1:IRS interaction brings SOS1 and p21 Ras into close proximity.
Takahashi, Y, Tobe, K, Kadowaki, H, Katsumata, D, Fukushima, Y, Yazaki, Y, Akanuma, Y, Kadowaki, T
Kim, B, Leventhal, PS, White, MF, Feldman, EL
Skolnik, EY, Batzer, A, Li, N, Lee, CH, Lowenstein, E, Mohammadi, M, Margolis, B, Schlessinger, J
Okada, S, Pessin, JE
Ward, CW, Gough, KH, Rashke, M, Wan, SS, Tribbick, G, Wang, J
Xu, B, Bird, VG, Miller, WT
Kim, B, Cheng, HL, Margolis, B, Feldman, EL
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