Inactive p21ras:GDP is anchored to the plasma membrane by a farnesyl residue. Insulin stimulation results in phosphorylation of IRS1/2 on tyrosine residues. GRB2 binds the phosphotyrosines via its SH2 domain. As IRS is phosphorylated by the insulin receptor near to the plasma membrane, the GRB2:SOS1:IRS interaction brings SOS1 and p21 Ras into close proximity.
White, MF, Feldman, EL, Leventhal, PS, Kim, B
Yazaki, Y, Kadowaki, T, Takahashi, Y, Tobe, K, Fukushima, Y, Kadowaki, H, Katsumata, D, Akanuma, Y
Batzer, A, Li, N, Schlessinger, J, Mohammadi, M, Skolnik, EY, Lowenstein, E, Margolis, B, Lee, CH
Pessin, JE, Okada, S
Ward, CW, Wang, J, Wan, SS, Gough, KH, Tribbick, G, Rashke, M
Bird, VG, Xu, B, Miller, WT
Feldman, EL, Cheng, HL, Margolis, B, Kim, B
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