Reactome | (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)

Schema > Reaction > Entries

(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) Show undefined attributes

catalystActivity	[CatalystActivity:109324] 5'-nucleotidase activity of NT5C2 tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643271] 5'-nucleotidase activity of NT5C2 tetramer [cytosol] Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
crossReference	[DatabaseIdentifier:12667762] RHEA:27715 [DatabaseIdentifier:9976355] RHEA:27715 [DatabaseIdentifier:9976336] RHEA:29380 [DatabaseIdentifier:9976361] RHEA:27719 [DatabaseIdentifier:9976350] RHEA:29384
dbId	74248
deleted	[Deleted:500122] Deletion of instances: 109332, 109325, 74250, 73822
displayName	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)
eventOf	[Pathway:R-HSA-74259] Purine catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose - Homo sapiens
input	[DefinedSet:R-ALL-500120] (d)GMP, (d)IMP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:109314] High Km soluble 5'-nucleotidase from human placenta [LiteratureReference:500117] Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition [LiteratureReference:109348] Cytosolic high Km 5'-nucleotidase and 5'(3')-deoxyribonucleotidase in substrate cycles involved in nucleotide metabolism [LiteratureReference:109319] Distinct roles for recombinant cytosolic 5'-nucleotidase I and -II in AMP and IMP catabolism in COS-7 and H9c2 rat myoblast cell lines [LiteratureReference:109306] Mammalian 5'-nucleotidases
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) GMP + H2O => guanosine + phosphate dGMP + H2O => 2'-deoxyguanosine + phosphate IMP + H2O => inosine + phosphate dIMP + H2O => 2'-deoxyinosine + phosphate
orthologousEvent	[Reaction:R-GGA-421179] inosine 5'-monophosphate (IMP) + H2O => inosine + orthophosphate - Gallus gallus [Reaction:R-DDI-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Dictyostelium discoideum [Reaction:R-CEL-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Caenorhabditis elegans [Reaction:R-DME-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Drosophila melanogaster [Reaction:R-GGA-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Gallus gallus [Reaction:R-XTR-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Xenopus tropicalis [Reaction:R-SSC-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Sus scrofa [Reaction:R-BTA-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Bos taurus [Reaction:R-CFA-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Canis familiaris [Reaction:R-RNO-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Rattus norvegicus [Reaction:R-MMU-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Mus musculus
output	[DefinedSet:R-ALL-500118] Gu-Rib, dG, Ino, dI [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-73797] FAICAR => IMP + H2O - Homo sapiens [Reaction:R-HSA-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Homo sapiens [Reaction:R-HSA-76590] AMP + H2O => IMP + NH4+ (AMPD) - Homo sapiens [Reaction:R-HSA-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-74248
summation	[Summation:178300] Cytosolic purine 5'-nucleotidase (NT5C2) catalyzes the hydro...
updateTrackers	[UpdateTracker:9790830] Update Tracker - [Reaction:74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9787381] Update Tracker - [Reaction:74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - v45:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790830] Update Tracker - [Reaction:74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9787381] Update Tracker - [Reaction:74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - v45:[modifyText]
(replacementInstances)	[Deleted:500122] Deletion of instances: 109332, 109325, 74250, 73822
(hasEvent)	[Pathway:R-HSA-74259] Purine catabolism
(precedingEvent)	[Reaction:R-HSA-74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose

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