Reactome | (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)

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(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) Show undefined attributes

catalystActivity	[CatalystActivity:10108241] 5'-nucleotidase activity of NT5C2 tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10108243
displayName	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)
eventOf	[Pathway:R-RNO-74259] Purine catabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Homo sapiens
input	[DefinedSet:R-ALL-500120] (d)GMP, (d)IMP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) GMP + H2O => guanosine + phosphate dGMP + H2O => 2'-deoxyguanosine + phosphate IMP + H2O => inosine + phosphate dIMP + H2O => 2'-deoxyinosine + phosphate
output	[DefinedSet:R-ALL-500118] Gu-Rib, dG, Ino, dI [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-RNO-73797] FAICAR => IMP + H2O - Rattus norvegicus [Reaction:R-RNO-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Rattus norvegicus [Reaction:R-RNO-76590] AMP + H2O => IMP + NH4+ (AMPD) - Rattus norvegicus [Reaction:R-RNO-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-74248
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-74259] Purine catabolism
(precedingEvent)	[Reaction:R-RNO-74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose
(inferredTo)	[Reaction:R-HSA-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)

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