Cytosolic purine 5'-nucleotidase (NT5C2) catalyzes the hydro...

created [InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
dbId 178300
displayName Cytosolic purine 5'-nucleotidase (NT5C2) catalyzes the hydro...
modified [InstanceEdit:3222067] D'Eustachio, P, 2013-03-18
schemaClass Summation
text Cytosolic purine 5'-nucleotidase (NT5C2) catalyzes the hydrolysis of GMP, dGMP, IMP, and dIMP to yield the corresponding nucleosides and orthophosphate (Bianchi and Spychala 2003; Spychala et al. 1988). The active form of the enzyme is a tetramer and has an absolute requirement for magnesium ions (Spychala et al. 1988; Wallden et al. 2007). Consistent with the biochemical properties of purified enzyme, cultured cells overexpressing the enzyme from a recombinant DNA clone showed enhanced activity against inosine and guanosine monophosphates, but not adenosine monophosphate (Gazziola et al. 2001; Sala-Newby et al. 2000).
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