Reactome | AMP + H2O => IMP + NH4+ (AMPD)

Schema > Reaction > Entries

AMP + H2O => IMP + NH4+ (AMPD) Show undefined attributes

catalystActivity	[CatalystActivity:76587] AMP deaminase activity of AMPD tetramers [cytosol]
catalystActivityReference	[CatalystActivityReference:9644036] AMP deaminase activity of AMPD tetramers [cytosol] Platelet AMP deaminase. Purification and kinetic studies
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:76579] D'Eustachio, P, 2003-10-11 14:30:00
crossReference	[DatabaseIdentifier:12667775] RHEA:14778 [DatabaseIdentifier:9976240] RHEA:14778
dbId	76590
deleted	[Deleted:500241] Deletion of instances: 76603, 76597
displayName	AMP + H2O => IMP + NH4+ (AMPD)
eventOf	[Pathway:R-HSA-74217] Purine salvage - Homo sapiens
followingEvent	[Reaction:R-HSA-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Homo sapiens
input	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:500239] Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA [LiteratureReference:500240] Novel aspects of tetramer assembly and N-terminal domain structure and function are revealed by recombinant expression of human AMP deaminase isoforms
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	AMP + H2O => IMP + NH4+ (AMPD) AMP + H2O + H(+) => IMP + NH4(+)
orthologousEvent	[Reaction:R-PFA-76590] AMP + H2O => IMP + NH4+ (AMPD) - Plasmodium falciparum [Reaction:R-SCE-76590] AMP + H2O => IMP + NH4+ (AMPD) - Saccharomyces cerevisiae [Reaction:R-SPO-76590] AMP + H2O => IMP + NH4+ (AMPD) - Schizosaccharomyces pombe [Reaction:R-DDI-76590] AMP + H2O => IMP + NH4+ (AMPD) - Dictyostelium discoideum [Reaction:R-CEL-76590] AMP + H2O => IMP + NH4+ (AMPD) - Caenorhabditis elegans [Reaction:R-DME-76590] AMP + H2O => IMP + NH4+ (AMPD) - Drosophila melanogaster [Reaction:R-GGA-76590] AMP + H2O => IMP + NH4+ (AMPD) - Gallus gallus [Reaction:R-XTR-76590] AMP + H2O => IMP + NH4+ (AMPD) - Xenopus tropicalis [Reaction:R-DRE-76590] AMP + H2O => IMP + NH4+ (AMPD) - Danio rerio [Reaction:R-SSC-76590] AMP + H2O => IMP + NH4+ (AMPD) - Sus scrofa [Reaction:R-BTA-76590] AMP + H2O => IMP + NH4+ (AMPD) - Bos taurus [Reaction:R-CFA-76590] AMP + H2O => IMP + NH4+ (AMPD) - Canis familiaris [Reaction:R-RNO-76590] AMP + H2O => IMP + NH4+ (AMPD) - Rattus norvegicus [Reaction:R-MMU-76590] AMP + H2O => IMP + NH4+ (AMPD) - Mus musculus
output	[SimpleEntity:R-ALL-29602] IMP [cytosol] [SimpleEntity:R-ALL-31633] NH4+ [cytosol]
precedingEvent	[Reaction:R-HSA-74213] APRT catalyzes the conversion of adenine to AMP - Homo sapiens [Reaction:R-HSA-73828] adenylosuccinate => adenosine 5'-monophosphate + fumarate - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-76590
summation	[Summation:178441] Cytosolic AMP deaminase (AMPD) catalyzes the hydrolysis of A...
updateTrackers	[UpdateTracker:9790790] Update Tracker - [Reaction:76590] AMP + H2O => IMP + NH4+ (AMPD) - v33:[add_removeOutput] [UpdateTracker:9791205] Update Tracker - [Reaction:76590] AMP + H2O => IMP + NH4+ (AMPD) - v32:[add_removeLiteratureReference, add_removeOutput, modifyText] [UpdateTracker:9984659] Update Tracker - [Reaction:76590] AMP + H2O => IMP + NH4+ (AMPD) - v96:[removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9790790] Update Tracker - [Reaction:76590] AMP + H2O => IMP + NH4+ (AMPD) - v33:[add_removeOutput] [UpdateTracker:9791205] Update Tracker - [Reaction:76590] AMP + H2O => IMP + NH4+ (AMPD) - v32:[add_removeLiteratureReference, add_removeOutput, modifyText] [UpdateTracker:9984659] Update Tracker - [Reaction:76590] AMP + H2O => IMP + NH4+ (AMPD) - v96:[removeInput]
(replacementInstances)	[Deleted:500241] Deletion of instances: 76603, 76597
(hasEvent)	[Pathway:R-HSA-74217] Purine salvage
(precedingEvent)	[Reaction:R-HSA-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)

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