Reactome | GNAT1-GTP binds PDE6 and activates it

Schema > Reaction > Entries

GNAT1-GTP binds PDE6 and activates it Show undefined attributes

authored	[InstanceEdit:73925] Schmidt, EE, 2003-07-11 09:09:49
category	binding
compartment	[Compartment:2514888] photoreceptor disc membrane [Compartment:70101] cytosol
created	[InstanceEdit:74965] Carleton, KL, 2003-07-31 08:44:54
dbId	74065
displayName	GNAT1-GTP binds PDE6 and activates it
edited	[InstanceEdit:2470272] Jassal, Bijay, 2012-09-18
eventOf	[Pathway:R-HSA-2485179] Activation of the phototransduction cascade - Homo sapiens
followingEvent	[Reaction:R-HSA-74059] PDE6 hydrolyses cGMP to GMP - Homo sapiens
inferredFrom	[Reaction:R-BTA-74066] Gnat1-GTP binds Pde6 and activates it - Bos taurus
input	[Complex:R-HSA-74049] GNAT1-GTP [photoreceptor disc membrane] [Complex:R-HSA-74055] PDE6 [photoreceptor disc membrane]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:74432] Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene [LiteratureReference:2534118] Genomic organization and complete sequence of the human gene encoding the beta-subunit of the cGMP phosphodiesterase and its localisation to 4p 16.3 [LiteratureReference:74440] Isolation and characterization of cDNA encoding the gamma-subunit of cGMP phosphodiesterase in human retina
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GNAT1-GTP binds PDE6 and activates it
output	[Complex:R-HSA-74056] GNAT1-GTP:PDE6 [photoreceptor disc membrane]
precedingEvent	[Reaction:R-HSA-2485182] Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-5603168] Negative regulation by 'GNAT1-GDP [photoreceptor disc membrane]'
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3270610] Makino, C, 2013-04-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-74065
summation	[Summation:2514876] The membrane associated cGMP phosphodiesterase 6 (PDE6) is a...
updateTrackers	[UpdateTracker:9785975] Update Tracker - [Reaction:74065] GNAT1-GTP binds PDE6 and activates it - v50:[add_removeRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9785975] Update Tracker - [Reaction:74065] GNAT1-GTP binds PDE6 and activates it - v50:[add_removeRegulator, modifyText]
(hasEvent)	[Pathway:R-HSA-2485179] Activation of the phototransduction cascade
(precedingEvent)	[Reaction:R-HSA-74059] PDE6 hydrolyses cGMP to GMP
(inferredTo)	[Reaction:R-BTA-74066] Gnat1-GTP binds Pde6 and activates it