Reactome | GMP [cytosol]

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GMP [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-CFA-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Canis familiaris [Reaction:R-BTA-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Bos taurus [Reaction:R-HSA-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Homo sapiens [Reaction:R-GGA-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Gallus gallus [Reaction:R-DRE-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Danio rerio [Reaction:R-CEL-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Caenorhabditis elegans [Reaction:R-RNO-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Rattus norvegicus [Reaction:R-SSC-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Sus scrofa [Reaction:R-MMU-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Mus musculus [Reaction:R-PFA-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Plasmodium falciparum
created	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
crossReference	[DatabaseIdentifier:29627] COMPOUND:C00144
dbId	113578
displayName	GMP [cytosol]
inDisease	false
memberOf	[DefinedSet:R-ALL-500260] GMP, IMP [cytosol] [DefinedSet:R-ALL-500120] (d)GMP, (d)IMP [cytosol] [DefinedSet:R-ALL-500071] (d)GMP [cytosol] [DefinedSet:R-ALL-500125] (d)AMP, (d)GMP, (d)IMP [cytosol]
modified	[InstanceEdit:9690506] Jassal, Bijay, 2020-06-02
name	GMP guanosine 5'-monophosphate Guanosine 5'-phosphate Guanosine monophosphate Guanylic acid
negativelyRegulates	[NegativeRegulation:R-HSA-111531] Negative regulation by 'GMP [cytosol]' [NegativeRegulation:R-MMU-111521] Negative regulation by 'guanosine 5'-monophosphate [cytosol]' [NegativeRegulation:R-GGA-420918] Negative regulation by 'guanosine 5'-monophosphate [cytosol]'
positivelyRegulates	[PositiveRegulation:R-HSA-111287] Positive regulation by 'GMP [cytosol]' [PositiveRegulation:R-GGA-420921] Positive regulation by 'guanosine 5'-monophosphate [cytosol]'
producedByEvent	[Reaction:R-HSA-74059] PDE6 hydrolyses cGMP to GMP - Homo sapiens [Reaction:R-PFA-418456] cGMP is degraded by PDEs - Plasmodium falciparum [Reaction:R-SSC-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Sus scrofa [Reaction:R-CFA-74059] PDE6 hydrolyses cGMP to GMP - Canis familiaris [Reaction:R-GGA-418456] cGMP is degraded by PDEs - Gallus gallus [Reaction:R-HSA-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Homo sapiens [Reaction:R-CEL-418456] cGMP is degraded by PDEs - Caenorhabditis elegans [Reaction:R-CFA-4086392] PDE6 hydrolyses cGMP to GMP - Canis familiaris [Reaction:R-MMU-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Mus musculus [Reaction:R-HSA-429845] 5' to 3' exoribonuclease hydrolyzes decapped mRNA - Homo sapiens [Reaction:R-GGA-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Gallus gallus [Reaction:R-SSC-4086392] PDE6 hydrolyses cGMP to GMP - Sus scrofa [Reaction:R-MMU-418456] cGMP is degraded by PDEs - Mus musculus [Reaction:R-SCE-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Saccharomyces cerevisiae [Reaction:R-MMU-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Mus musculus [Reaction:R-GGA-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Gallus gallus [Reaction:R-CFA-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Canis familiaris [Reaction:R-RNO-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Rattus norvegicus [Reaction:R-SCE-418456] cGMP is degraded by PDEs - Saccharomyces cerevisiae [Reaction:R-RNO-418456] cGMP is degraded by PDEs - Rattus norvegicus [Reaction:R-HSA-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Homo sapiens [Reaction:R-GGA-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Gallus gallus [Reaction:R-HSA-418456] cGMP is degraded by PDEs - Homo sapiens [Reaction:R-SCE-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Saccharomyces cerevisiae [Reaction:R-CFA-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Canis familiaris [Reaction:R-SPO-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Schizosaccharomyces pombe [Reaction:R-XTR-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Xenopus tropicalis [Reaction:R-XTR-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Xenopus tropicalis [Reaction:R-DME-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Drosophila melanogaster [Reaction:R-DRE-4086392] PDE6 hydrolyses cGMP to GMP - Danio rerio [Reaction:R-DME-418456] cGMP is degraded by PDEs - Drosophila melanogaster [Reaction:R-DRE-418456] cGMP is degraded by PDEs - Danio rerio [Reaction:R-PFA-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Plasmodium falciparum [Reaction:R-HSA-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Homo sapiens [Reaction:R-DDI-418456] cGMP is degraded by PDEs - Dictyostelium discoideum [Reaction:R-MMU-4086392] PDE6 hydrolyses cGMP to GMP - Mus musculus [Reaction:R-HSA-4086392] PDE6 hydrolyses cGMP to GMP - Homo sapiens [Reaction:R-BTA-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Bos taurus [Reaction:R-DRE-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Danio rerio [Reaction:R-DRE-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Danio rerio [Reaction:R-SSC-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Sus scrofa [Reaction:R-RNO-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Rattus norvegicus [Reaction:R-DRE-74059] PDE6 hydrolyses cGMP to GMP - Danio rerio [Reaction:R-SSC-418456] cGMP is degraded by PDEs - Sus scrofa [Reaction:R-SPO-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Schizosaccharomyces pombe [Reaction:R-GGA-421218] xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate - Gallus gallus [Reaction:R-DDI-4086392] PDE6 hydrolyses cGMP to GMP - Dictyostelium discoideum [Reaction:R-CFA-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Canis familiaris [Reaction:R-GGA-4086392] PDE6 hydrolyses cGMP to GMP - Gallus gallus [Reaction:R-SSC-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Sus scrofa [Reaction:R-CEL-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Caenorhabditis elegans [Reaction:R-BTA-418456] cGMP is degraded by PDEs - Bos taurus [Reaction:R-DDI-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Dictyostelium discoideum [Reaction:R-DDI-74059] PDE6 hydrolyses cGMP to GMP - Dictyostelium discoideum [Reaction:R-CEL-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Caenorhabditis elegans [Reaction:R-DME-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Drosophila melanogaster [Reaction:R-CFA-418456] cGMP is degraded by PDEs - Canis familiaris [Reaction:R-MMU-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Mus musculus [Reaction:R-RNO-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Rattus norvegicus [Reaction:R-SSC-74059] PDE6 hydrolyses cGMP to GMP - Sus scrofa [Reaction:R-DME-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Drosophila melanogaster [Reaction:R-MMU-74059] PDE6 hydrolyses cGMP to GMP - Mus musculus [Reaction:R-CEL-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Caenorhabditis elegans [Reaction:R-RNO-4086392] PDE6 hydrolyses cGMP to GMP - Rattus norvegicus [Reaction:R-SCE-429913] 5' to 3' Exoribonuclease Digestion of Decapped mRNA (yeast) - Saccharomyces cerevisiae [Reaction:R-BTA-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Bos taurus [Reaction:R-DRE-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Danio rerio [Reaction:R-DDI-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Dictyostelium discoideum [Reaction:R-RNO-74059] PDE6 hydrolyses cGMP to GMP - Rattus norvegicus
referenceEntity	[ReferenceMolecule:114791] guanosine 5'-monophosphate [ChEBI:17345]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-113578

Referrals

(input)	[Reaction:R-PFA-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Plasmodium falciparum [Reaction:R-HSA-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Homo sapiens [Reaction:R-MMU-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Mus musculus [Reaction:R-RNO-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Rattus norvegicus [Reaction:R-CFA-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Canis familiaris [Reaction:R-BTA-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Bos taurus [Reaction:R-SSC-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Sus scrofa [Reaction:R-DRE-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Danio rerio [Reaction:R-GGA-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Gallus gallus [Reaction:R-CEL-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Caenorhabditis elegans
(output)	[Reaction:R-GGA-421218] xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate - Gallus gallus [Reaction:R-PFA-418456] cGMP is degraded by PDEs - Plasmodium falciparum [Reaction:R-SCE-418456] cGMP is degraded by PDEs - Saccharomyces cerevisiae [Reaction:R-DDI-418456] cGMP is degraded by PDEs - Dictyostelium discoideum [Reaction:R-CEL-418456] cGMP is degraded by PDEs - Caenorhabditis elegans [Reaction:R-DME-418456] cGMP is degraded by PDEs - Drosophila melanogaster [Reaction:R-GGA-418456] cGMP is degraded by PDEs - Gallus gallus [Reaction:R-DRE-418456] cGMP is degraded by PDEs - Danio rerio [Reaction:R-SSC-418456] cGMP is degraded by PDEs - Sus scrofa [Reaction:R-BTA-418456] cGMP is degraded by PDEs - Bos taurus [Reaction:R-CFA-418456] cGMP is degraded by PDEs - Canis familiaris [Reaction:R-RNO-418456] cGMP is degraded by PDEs - Rattus norvegicus [Reaction:R-MMU-418456] cGMP is degraded by PDEs - Mus musculus [Reaction:R-HSA-418456] cGMP is degraded by PDEs - Homo sapiens [Reaction:R-CEL-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Caenorhabditis elegans [Reaction:R-DME-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Drosophila melanogaster [Reaction:R-GGA-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Gallus gallus [Reaction:R-XTR-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Xenopus tropicalis [Reaction:R-DRE-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Danio rerio [Reaction:R-SSC-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Sus scrofa [Reaction:R-BTA-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Bos taurus [Reaction:R-CFA-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Canis familiaris [Reaction:R-RNO-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Rattus norvegicus [Reaction:R-MMU-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Mus musculus [Reaction:R-HSA-744230] SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP - Homo sapiens [Reaction:R-DDI-74059] PDE6 hydrolyses cGMP to GMP - Dictyostelium discoideum [Reaction:R-DRE-74059] PDE6 hydrolyses cGMP to GMP - Danio rerio [Reaction:R-SSC-74059] PDE6 hydrolyses cGMP to GMP - Sus scrofa [Reaction:R-CFA-74059] PDE6 hydrolyses cGMP to GMP - Canis familiaris [Reaction:R-RNO-74059] PDE6 hydrolyses cGMP to GMP - Rattus norvegicus [Reaction:R-HSA-74059] PDE6 hydrolyses cGMP to GMP - Homo sapiens [Reaction:R-MMU-74059] PDE6 hydrolyses cGMP to GMP - Mus musculus [Reaction:R-SCE-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Saccharomyces cerevisiae [Reaction:R-SPO-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Schizosaccharomyces pombe [Reaction:R-DDI-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Dictyostelium discoideum [Reaction:R-CEL-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Caenorhabditis elegans [Reaction:R-DME-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Drosophila melanogaster [Reaction:R-GGA-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Gallus gallus [Reaction:R-DRE-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Danio rerio [Reaction:R-SSC-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Sus scrofa [Reaction:R-CFA-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Canis familiaris [Reaction:R-MMU-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Mus musculus [Reaction:R-HSA-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Homo sapiens [Reaction:R-HSA-4086392] PDE6 hydrolyses cGMP to GMP - Homo sapiens [Reaction:R-MMU-4086392] PDE6 hydrolyses cGMP to GMP - Mus musculus [Reaction:R-RNO-4086392] PDE6 hydrolyses cGMP to GMP - Rattus norvegicus [Reaction:R-CFA-4086392] PDE6 hydrolyses cGMP to GMP - Canis familiaris [Reaction:R-SSC-4086392] PDE6 hydrolyses cGMP to GMP - Sus scrofa [Reaction:R-DRE-4086392] PDE6 hydrolyses cGMP to GMP - Danio rerio [Reaction:R-GGA-4086392] PDE6 hydrolyses cGMP to GMP - Gallus gallus [Reaction:R-DDI-4086392] PDE6 hydrolyses cGMP to GMP - Dictyostelium discoideum [Reaction:R-RNO-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Rattus norvegicus [Reaction:R-HSA-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Homo sapiens [Reaction:R-MMU-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Mus musculus [Reaction:R-CFA-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Canis familiaris [Reaction:R-BTA-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Bos taurus [Reaction:R-SSC-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Sus scrofa [Reaction:R-DRE-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Danio rerio [Reaction:R-XTR-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Xenopus tropicalis [Reaction:R-GGA-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Gallus gallus [Reaction:R-DME-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Drosophila melanogaster [Reaction:R-CEL-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Caenorhabditis elegans [Reaction:R-DDI-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Dictyostelium discoideum [Reaction:R-SPO-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Schizosaccharomyces pombe [Reaction:R-SCE-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Saccharomyces cerevisiae [Reaction:R-PFA-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Plasmodium falciparum [Reaction:R-HSA-429845] 5' to 3' exoribonuclease hydrolyzes decapped mRNA - Homo sapiens [Reaction:R-SCE-429913] 5' to 3' Exoribonuclease Digestion of Decapped mRNA (yeast) - Saccharomyces cerevisiae [Reaction:R-RNO-430028] Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion - Rattus norvegicus
(hasMember)	[DefinedSet:R-ALL-500260] GMP, IMP [cytosol] [DefinedSet:R-ALL-500120] (d)GMP, (d)IMP [cytosol] [DefinedSet:R-ALL-500125] (d)AMP, (d)GMP, (d)IMP [cytosol] [DefinedSet:R-ALL-500071] (d)GMP [cytosol]
(regulator)	[NegativeRegulation:R-HSA-111531] Negative regulation by 'GMP [cytosol]' [NegativeRegulation:R-MMU-111521] Negative regulation by 'guanosine 5'-monophosphate [cytosol]' [NegativeRegulation:R-GGA-420918] Negative regulation by 'guanosine 5'-monophosphate [cytosol]' [PositiveRegulation:R-HSA-111287] Positive regulation by 'GMP [cytosol]' [PositiveRegulation:R-GGA-420921] Positive regulation by 'guanosine 5'-monophosphate [cytosol]'

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