Reactome | Activation of the phototransduction cascade

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Activation of the phototransduction cascade Show undefined attributes

authored	[InstanceEdit:2485181] Jassal, Bijay, 2012-10-01
created	[InstanceEdit:2485181] Jassal, Bijay, 2012-10-01
dbId	2485179
displayName	Activation of the phototransduction cascade
edited	[InstanceEdit:2485181] Jassal, Bijay, 2012-10-01
eventOf	[Pathway:R-HSA-2514856] The phototransduction cascade - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:21771] G protein-coupled opsin signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-74101] Photons induce isomerization of 11c-retinyl to at-retinyl - Homo sapiens [Reaction:R-HSA-2485180] MII catalyses GDP/GTP exchange on Gt - Homo sapiens [Reaction:R-HSA-2485182] Gt-GTP dissociates to GNAT1-GTP and GNB1:GNGT1 - Homo sapiens [Reaction:R-HSA-74065] GNAT1-GTP binds PDE6 and activates it - Homo sapiens [Reaction:R-HSA-74059] PDE6 hydrolyses cGMP to GMP - Homo sapiens [Reaction:R-HSA-2514867] cGMP:CNG transports Na+ and Ca2+ into the rod outer segment - Homo sapiens [Reaction:R-HSA-2514891] SLC24A1 exchanges 4Na+ for Ca2+, K+ - Homo sapiens [Reaction:R-HSA-2514865] cGMP dissociates from CNG channels - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2020-06-17
literatureReference	[LiteratureReference:3222200] Lessons from photoreceptors: turning off G-protein signaling in living cells [LiteratureReference:3222186] Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: facts and models [LiteratureReference:3222188] Amplification and kinetics of the activation steps in phototransduction
maxDepth	2
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Activation of the phototransduction cascade
orthologousEvent	[Pathway:R-MMU-2485179] Activation of the phototransduction cascade - Mus musculus [Pathway:R-DDI-2485179] Activation of the phototransduction cascade - Dictyostelium discoideum [Pathway:R-CEL-2485179] Activation of the phototransduction cascade - Caenorhabditis elegans [Pathway:R-DME-2485179] Activation of the phototransduction cascade - Drosophila melanogaster [Pathway:R-GGA-2485179] Activation of the phototransduction cascade - Gallus gallus [Pathway:R-XTR-2485179] Activation of the phototransduction cascade - Xenopus tropicalis [Pathway:R-DRE-2485179] Activation of the phototransduction cascade - Danio rerio [Pathway:R-SSC-2485179] Activation of the phototransduction cascade - Sus scrofa [Pathway:R-BTA-2485179] Activation of the phototransduction cascade - Bos taurus [Pathway:R-CFA-2485179] Activation of the phototransduction cascade - Canis familiaris [Pathway:R-RNO-2485179] Activation of the phototransduction cascade - Rattus norvegicus
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3270610] Makino, C, 2013-04-11
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2485179
summation	[Summation:2514857] The photoreceptor cascade starts with light isomerization of...
updateTrackers	[UpdateTracker:9782454] Update Tracker - [Pathway:2485179] Activation of the phototransduction cascade - v59:[updateContainedRLE] [UpdateTracker:9786226] Update Tracker - [Pathway:2485179] Activation of the phototransduction cascade - v50:[updateContainedRLE] [UpdateTracker:9776919] Update Tracker - [Pathway:2485179] Activation of the phototransduction cascade - v73:[updateContainedRLE] [UpdateTracker:9786732] Update Tracker - [Pathway:2485179] Activation of the phototransduction cascade - v48:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9782454] Update Tracker - [Pathway:2485179] Activation of the phototransduction cascade - v59:[updateContainedRLE]
[UpdateTracker:9786226] Update Tracker - [Pathway:2485179] Activation of the phototransduction cascade - v50:[updateContainedRLE]
[UpdateTracker:9776919] Update Tracker - [Pathway:2485179] Activation of the phototransduction cascade - v73:[updateContainedRLE]
[UpdateTracker:9786732] Update Tracker - [Pathway:2485179] Activation of the phototransduction cascade - v48:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-2514856] The phototransduction cascade

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