Reactome | Formation of phosphoribosyl pyrophosphate amidotransferase tetramer

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Formation of phosphoribosyl pyrophosphate amidotransferase tetramer Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:111282] D'Eustachio, P, 2004-02-11 12:18:00
dbId	111285
displayName	Formation of phosphoribosyl pyrophosphate amidotransferase tetramer
eventOf	[Pathway:R-HSA-73817] Purine ribonucleoside monophosphate biosynthesis - Homo sapiens
input	2 × [Complex:R-HSA-73790] PPAT dimer [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111230] Human glutamine phosphoribosylpyrophosphate amidotransferase. Kinetic and regulatory properties [LiteratureReference:111231] Human glutamine phosphoribosylpyrophosphate amidotransferase. Two molecular forms interconvertible by purine ribonucleotides and phosphoribosylpyrophosphate
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Formation of phosphoribosyl pyrophosphate amidotransferase tetramer
negativePrecedingEvent	[NegativePrecedingEvent:9765095] Futile Cycle: Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
orthologousEvent	[Reaction:R-CEL-111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer - Caenorhabditis elegans [Reaction:R-DME-111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer - Drosophila melanogaster [Reaction:R-GGA-111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer - Gallus gallus [Reaction:R-XTR-111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer - Xenopus tropicalis [Reaction:R-DRE-111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer - Danio rerio [Reaction:R-SSC-111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer - Sus scrofa [Reaction:R-BTA-111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer - Bos taurus [Reaction:R-CFA-111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer - Canis familiaris [Reaction:R-RNO-111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer - Rattus norvegicus [Reaction:R-MMU-111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer - Mus musculus
output	[Complex:R-HSA-73789] PPAT tetramer [cytosol]
precedingEvent	[Reaction:R-HSA-73797] FAICAR => IMP + H2O - Homo sapiens [Reaction:R-HSA-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Homo sapiens [Reaction:R-HSA-73828] adenylosuccinate => adenosine 5'-monophosphate + fumarate - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-111286] Positive regulation by 'adenosine 5'-monophosphate [cytosol]' [PositiveRegulation:R-HSA-111287] Positive regulation by 'GMP [cytosol]' [PositiveRegulation:R-HSA-111288] Positive regulation by 'IMP [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-111285
summation	[Summation:178791] Cytosolic AMP, GMP, and IMP stimulate the association of pho...
updateTrackers	[UpdateTracker:9790157] Update Tracker - [Reaction:111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer - v35:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790157] Update Tracker - [Reaction:111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer - v35:[modifyText]
(hasEvent)	[Pathway:R-HSA-73817] Purine ribonucleoside monophosphate biosynthesis
(precedingEvent)	[NegativePrecedingEvent:9765094] Futile Cycle: Formation of phosphoribosyl pyrophosphate amidotransferase tetramer

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