Reactome | IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]

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IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] Show undefined attributes

authored	[InstanceEdit:111552] D'Eustachio, P, 2004-02-23 10:40:00
catalystActivity	[CatalystActivity:73793] IMP dehydrogenase activity of IMPDH tetramers [cytosol]
catalystActivityReference	[CatalystActivityReference:9643517] IMP dehydrogenase activity of IMPDH tetramers [cytosol] Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
crossReference	[DatabaseIdentifier:11880035] Rhea:11709
dbId	73794
displayName	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-73817] Purine ribonucleoside monophosphate biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29602] IMP [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111563] Characterization of human type I and type II IMP dehydrogenases
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+
orthologousEvent	[Reaction:R-GGA-421222] inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+ - Gallus gallus [Reaction:R-PFA-73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - Plasmodium falciparum [Reaction:R-SCE-73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - Saccharomyces cerevisiae [Reaction:R-SPO-73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - Schizosaccharomyces pombe [Reaction:R-DDI-73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - Dictyostelium discoideum [Reaction:R-CEL-73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - Caenorhabditis elegans [Reaction:R-DME-73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - Drosophila melanogaster [Reaction:R-GGA-73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - Gallus gallus [Reaction:R-XTR-73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - Xenopus tropicalis [Reaction:R-DRE-73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - Danio rerio [Reaction:R-SSC-73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - Sus scrofa [Reaction:R-BTA-73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - Bos taurus [Reaction:R-CFA-73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - Canis familiaris [Reaction:R-RNO-73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - Rattus norvegicus [Reaction:R-MMU-73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - Mus musculus
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol] [SimpleEntity:R-ALL-111584] XMP [cytosol]
precedingEvent	[Reaction:R-HSA-73797] FAICAR => IMP + H2O - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-111589] Negative regulation by 'XMP [cytosol]' [NegativeRegulation:9690505] Negative regulation by 'IMPDH tetramers:IMPDH inhibitors [cytosol]'
regulationReference	[RegulationReference:9690507] Negative regulation by 'IMPDH tetramers:IMPDH inhibitors [cytosol]' Synthesis and immunosuppressive activity of some side-chain variants of mycophenolic acid
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73794
summation	[Summation:111588] Two human isoenzymes, IMP dehydrogenase 1 and 2 (IMPDH1,2) c...

Referrals

(hasEvent)	[Pathway:R-HSA-73817] Purine ribonucleoside monophosphate biosynthesis
(precedingEvent)	[Reaction:R-HSA-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate