Reactome | AICAR + 10-Formyl-THF => FAICAR + THF

Schema > Reaction > Entries

AICAR + 10-Formyl-THF => FAICAR + THF Show undefined attributes

authored	[InstanceEdit:111407] D'Eustachio, P, 2004-02-12 14:16:00
catalystActivity	[CatalystActivity:73796] phosphoribosylaminoimidazolecarboxamide formyltransferase activity of ATIC dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73784] Jassal, B, 2003-06-26 04:06:16
crossReference	[DatabaseIdentifier:9975682] RHEA:22193
dbId	73798
displayName	AICAR + 10-Formyl-THF => FAICAR + THF
edited	[InstanceEdit:165089] D'Eustachio, P, Jassal, B, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-73817] Purine ribonucleoside monophosphate biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-73797] FAICAR => IMP + H2O - Homo sapiens
input	[SimpleEntity:R-ALL-419151] 10-formyl-THF [cytosol] [SimpleEntity:R-ALL-111409] AICAR [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111425] The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [LiteratureReference:111426] Human 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity [LiteratureReference:419266] Reversible compartmentalization of de novo purine biosynthetic complexes in living cells
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	AICAR + 10-Formyl-THF => FAICAR + THF (6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide => 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate
orthologousEvent	[Reaction:R-SCE-73798] AICAR + 10-Formyl-THF => FAICAR + THF - Saccharomyces cerevisiae [Reaction:R-SPO-73798] AICAR + 10-Formyl-THF => FAICAR + THF - Schizosaccharomyces pombe [Reaction:R-DDI-73798] AICAR + 10-Formyl-THF => FAICAR + THF - Dictyostelium discoideum [Reaction:R-CEL-73798] AICAR + 10-Formyl-THF => FAICAR + THF - Caenorhabditis elegans [Reaction:R-DME-73798] AICAR + 10-Formyl-THF => FAICAR + THF - Drosophila melanogaster [Reaction:R-GGA-73798] AICAR + 10-Formyl-THF => FAICAR + THF - Gallus gallus [Reaction:R-XTR-73798] AICAR + 10-Formyl-THF => FAICAR + THF - Xenopus tropicalis [Reaction:R-DRE-73798] AICAR + 10-Formyl-THF => FAICAR + THF - Danio rerio [Reaction:R-SSC-73798] AICAR + 10-Formyl-THF => FAICAR + THF - Sus scrofa [Reaction:R-BTA-73798] AICAR + 10-Formyl-THF => FAICAR + THF - Bos taurus [Reaction:R-CFA-73798] AICAR + 10-Formyl-THF => FAICAR + THF - Canis familiaris [Reaction:R-RNO-73798] AICAR + 10-Formyl-THF => FAICAR + THF - Rattus norvegicus [Reaction:R-MMU-73798] AICAR + 10-Formyl-THF => FAICAR + THF - Mus musculus
output	[SimpleEntity:R-ALL-111427] FAICAR [cytosol] [SimpleEntity:R-ALL-111355] THF [cytosol]
precedingEvent	[Reaction:R-HSA-73800] SAICAR => AICAR + Fumarate - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73798
summation	[Summation:111429] The irreversible transfer of a formyl group to 5'-phosphorib...
updateTrackers	[UpdateTracker:9791550] Update Tracker - [Reaction:73798] AICAR + 10-Formyl-THF => FAICAR + THF - v29:[addLiteratureReference, add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791550] Update Tracker - [Reaction:73798] AICAR + 10-Formyl-THF => FAICAR + THF - v29:[addLiteratureReference, add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-73817] Purine ribonucleoside monophosphate biosynthesis
(precedingEvent)	[Reaction:R-HSA-73797] FAICAR => IMP + H2O

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