Reactome | Purine ribonucleoside monophosphate biosynthesis

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Purine ribonucleoside monophosphate biosynthesis Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10910758
displayName	Purine ribonucleoside monophosphate biosynthesis
eventOf	[Pathway:R-DME-8956320] Nucleotide biosynthesis - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:15969] purine ribonucleoside monophosphate biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-111285] Formation of phosphoribosyl pyrophosphate amidotransferase tetramer - Drosophila melanogaster [Reaction:R-DME-111289] Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer - Drosophila melanogaster [Reaction:R-DME-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Drosophila melanogaster [Reaction:R-DME-73814] 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi - Drosophila melanogaster [Reaction:R-DME-73813] GAR + 10-Formyl-THF => FGAR + THF - Drosophila melanogaster [Reaction:R-DME-73812] FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi - Drosophila melanogaster [Reaction:R-DME-73810] FGAM + ATP => AIR + ADP + Pi - Drosophila melanogaster [Reaction:R-DME-73806] AIR + CO2 => CAIR - Drosophila melanogaster [Reaction:R-DME-73805] CAIR + Aspartate + ATP => SAICAR + ADP + Pi - Drosophila melanogaster [Reaction:R-DME-73800] SAICAR => AICAR + Fumarate - Drosophila melanogaster [Reaction:R-DME-73798] AICAR + 10-Formyl-THF => FAICAR + THF - Drosophila melanogaster [Reaction:R-DME-73797] FAICAR => IMP + H2O - Drosophila melanogaster [Reaction:R-DME-73794] IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] - Drosophila melanogaster [Reaction:R-DME-9678749] IMPDH tetramers bind IMPDH inhibitors - Drosophila melanogaster [Reaction:R-DME-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Drosophila melanogaster [Reaction:R-DME-111524] IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] - Drosophila melanogaster [Reaction:R-DME-73828] adenylosuccinate => adenosine 5'-monophosphate + fumarate - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-73817] Purine ribonucleoside monophosphate biosynthesis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Purine ribonucleoside monophosphate biosynthesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-73817
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-8956320] Nucleotide biosynthesis
(inferredTo)	[Pathway:R-HSA-73817] Purine ribonucleoside monophosphate biosynthesis

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