Reactome | 2xHC-TXN [cytosol]

Schema > EntityWithAccessionedSequence > Entries

2xHC-TXN [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-1250249] Oxidized thioredoxin:TXNIP [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-73646] Regeneration of active (reduced) Thioredoxin - Homo sapiens
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
dbId	73668
deleted	[Deleted:8866415] Deletion of instance: 111802
displayName	2xHC-TXN [cytosol]
endCoordinate	105
hasModifiedResidue	[IntraChainCrosslinkedResidue:111706] Intra-chain Crosslink via L-cystine (cross-link) at 32 and 35
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-73668] Txn [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-73668] Txn [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-73668] TXN [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-73668] TXN [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-73668] 2xHC-TXN [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-SSC-73668-2] TXN [cytosol] - Sus scrofa [DefinedSet:R-SSC-73668-3] Homologues of 2xHC-TXN [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-73668] txna [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-GGA-73668] TXN [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-73668] Trx2 [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-73668] trx-1 [cytosol] - Caenorhabditis elegans
maxDepth	1
modified	[InstanceEdit:9686253] May, Bruce, 2020-04-29
name	2xHC-TXN Thioredoxin, oxidized Thioredoxin ATL-derived factor ADF Surface associated sulphydryl protein SASP
producedByEvent	[BlackBoxEvent:R-HSA-1250280] ROS oxidize thioredoxin - Homo sapiens [Reaction:R-HSA-1250253] TXNIP is released from oxidized thioredoxin - Homo sapiens [Reaction:R-HSA-5676940] MSRA reduces L-methyl-(S)-S-oxide to L-Methionine - Homo sapiens [Reaction:R-HSA-5676917] MRSBs reduce L-methyl-(R)-S-oxide to L-methionine - Homo sapiens [Reaction:R-HSA-111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Homo sapiens [Reaction:R-HSA-111804] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Homo sapiens [Reaction:R-HSA-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Homo sapiens [Reaction:R-HSA-3225851] ROS oxidize thioredoxin and activate MAP3K5 - Homo sapiens [Reaction:R-HSA-3697882] PRDX5 reduces peroxynitrite to nitrite using TXN - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P10599] UniProt:P10599 TXN
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-73668
startCoordinate	2
updateTrackers	[UpdateTracker:9901226] Update Tracker - [EntityWithAccessionedSequence:73668] 2xHC-TXN [cytosol] - v73:[removeHasModifiedResidue] [UpdateTracker:9870096] Update Tracker - [EntityWithAccessionedSequence:73668] 2xHC-TXN [cytosol] - v37:[modifyName] [UpdateTracker:9878407] Update Tracker - [EntityWithAccessionedSequence:73668] 2xHC-TXN [cytosol] - v44:[modifyEndCoordinate, modifyStartCoordinate] [UpdateTracker:9886831] Update Tracker - [EntityWithAccessionedSequence:73668] 2xHC-TXN [cytosol] - v45:[addName]

Referrals

(updatedInstance)	[UpdateTracker:9901226] Update Tracker - [EntityWithAccessionedSequence:73668] 2xHC-TXN [cytosol] - v73:[removeHasModifiedResidue] [UpdateTracker:9870096] Update Tracker - [EntityWithAccessionedSequence:73668] 2xHC-TXN [cytosol] - v37:[modifyName] [UpdateTracker:9878407] Update Tracker - [EntityWithAccessionedSequence:73668] 2xHC-TXN [cytosol] - v44:[modifyEndCoordinate, modifyStartCoordinate] [UpdateTracker:9886831] Update Tracker - [EntityWithAccessionedSequence:73668] 2xHC-TXN [cytosol] - v45:[addName]
(replacementInstances)	[Deleted:8866415] Deletion of instance: 111802
(output)	[Reaction:R-HSA-5676940] MSRA reduces L-methyl-(S)-S-oxide to L-Methionine [Reaction:R-HSA-5676917] MRSBs reduce L-methyl-(R)-S-oxide to L-methionine [Reaction:R-HSA-111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) [Reaction:R-HSA-111804] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) [Reaction:R-HSA-3697882] PRDX5 reduces peroxynitrite to nitrite using TXN [Reaction:R-HSA-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O [BlackBoxEvent:R-HSA-1250280] ROS oxidize thioredoxin [Reaction:R-HSA-1250253] TXNIP is released from oxidized thioredoxin [Reaction:R-HSA-3225851] ROS oxidize thioredoxin and activate MAP3K5
(input)	[Reaction:R-HSA-73646] Regeneration of active (reduced) Thioredoxin
(hasComponent)	[Complex:R-HSA-1250249] Oxidized thioredoxin:TXNIP [cytosol]

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