Reactome | RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)

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RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) Show undefined attributes

catalystActivity	[CatalystActivity:8866404] ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor of RNR (M1M2) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:111698] D'Eustachio, P, 2004-03-17 17:27:00
crossReference	[DatabaseIdentifier:9975913] RHEA:23254
dbId	111751
deleted	[Deleted:499950] Deletion of instance: 111752 [Deleted:499954] Deletion of instances: 74227, 74202, 73645, 73644
displayName	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)
eventOf	[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates - Homo sapiens
input	[SimpleEntity:R-ALL-8866401] NDP(3-) [cytosol] [EntityWithAccessionedSequence:R-HSA-66000] TXN [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111731] Structure and function of the radical enzyme ribonucleotide reductase [LiteratureReference:111723] Thioredoxin and glutaredoxin systems [LiteratureReference:9737134] Ribonucleotide reductases [LiteratureReference:8866393] Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage [LiteratureReference:111734] Cross-talk between the allosteric effector-binding sites in mouse ribonucleotide reductase [LiteratureReference:111743] The NMR solution structure of human glutaredoxin in the fully reduced form [LiteratureReference:499990] A dityrosyl-diiron radical cofactor center is essential for human ribonucleotide reductases [LiteratureReference:8866460] Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) a ribonucleoside 5'-diphosphate + (thioredoxin)-dithiol => a 2'-deoxyribonucleoside 5'-diphosphate + (thioredoxin)-disulfide + H2O NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O
orthologousEvent	[Reaction:R-MMU-111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Mus musculus [Reaction:R-CEL-111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Caenorhabditis elegans [Reaction:R-DME-111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Drosophila melanogaster [Reaction:R-DRE-111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Danio rerio [Reaction:R-SSC-111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Sus scrofa [Reaction:R-BTA-111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Bos taurus [Reaction:R-CFA-111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Canis familiaris [Reaction:R-RNO-111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Rattus norvegicus
output	[EntityWithAccessionedSequence:R-HSA-73668] 2xHC-TXN [cytosol] [SimpleEntity:R-ALL-8866399] dNDP(3-) [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
precedingEvent	[Reaction:R-HSA-73646] Regeneration of active (reduced) Thioredoxin - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-111757] Positive regulation by 'ATP [cytosol]' [NegativeRegulation:R-HSA-111770] Negative regulation by 'dATP [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-111751
summation	[Summation:213076] Ribonucleotide reductase (RNR (M1M2)) catalyzes the reductio...
updateTrackers	[UpdateTracker:9783347] Update Tracker - [Reaction:111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - v57:[add_removeCatalystActivity, add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText] [UpdateTracker:9775974] Update Tracker - [Reaction:111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - v78:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783347] Update Tracker - [Reaction:111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - v57:[add_removeCatalystActivity, add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText] [UpdateTracker:9775974] Update Tracker - [Reaction:111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - v78:[addLiteratureReference, modifyText]
(replacementInstances)	[Deleted:499950] Deletion of instance: 111752 [Deleted:499954] Deletion of instances: 74227, 74202, 73645, 73644
(hasEvent)	[Pathway:R-HSA-499943] Interconversion of nucleotide di- and triphosphates