Reactome | Txn [cytosol]

compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-RNO-73646] Regeneration of active (reduced) Thioredoxin - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10107344
displayName	Txn [cytosol]
endCoordinate	105
hasModifiedResidue	[IntraChainCrosslinkedResidue:10107342] Intra-chain Crosslink via L-cystine (cross-link) at 32 and 35 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-73668] 2xHC-TXN [cytosol] - Homo sapiens
maxDepth	1
name	Txn 2xHC-TXN P11232
producedByEvent	[BlackBoxEvent:R-RNO-1250280] ROS oxidize thioredoxin - Rattus norvegicus [Reaction:R-RNO-5676940] MSRA reduces L-methyl-(S)-S-oxide to L-Methionine - Rattus norvegicus [Reaction:R-RNO-5676917] MRSBs reduce L-methyl-(R)-S-oxide to L-methionine - Rattus norvegicus [Reaction:R-RNO-111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Rattus norvegicus [Reaction:R-RNO-111804] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Rattus norvegicus [Reaction:R-RNO-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O - Rattus norvegicus [Reaction:R-RNO-3225851] ROS oxidize thioredoxin and activate MAP3K5 - Rattus norvegicus [Reaction:R-RNO-3697882] PRDX5 reduces peroxynitrite to nitrite using TXN - Rattus norvegicus
referenceEntity	[ReferenceGeneProduct:uniprot:P11232] UniProt:P11232
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48895] Rattus norvegicus
stId	R-RNO-73668
startCoordinate	2

(output)	[Reaction:R-RNO-5676940] MSRA reduces L-methyl-(S)-S-oxide to L-Methionine [Reaction:R-RNO-5676917] MRSBs reduce L-methyl-(R)-S-oxide to L-methionine [Reaction:R-RNO-111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) [Reaction:R-RNO-111804] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) [Reaction:R-RNO-3697882] PRDX5 reduces peroxynitrite to nitrite using TXN [Reaction:R-RNO-3341343] PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O [BlackBoxEvent:R-RNO-1250280] ROS oxidize thioredoxin [Reaction:R-RNO-3225851] ROS oxidize thioredoxin and activate MAP3K5
(input)	[Reaction:R-RNO-73646] Regeneration of active (reduced) Thioredoxin
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-73668] 2xHC-TXN [cytosol]

Txn [cytosol] Show undefined attributes

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