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Entries
5-Phosphoribose 1-diphosphate biosynthesis
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authored
[InstanceEdit:111173] D'Eustachio, P, 2004-02-09 03:00:00
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:73832] Jassal, B, 2003-07-03 08:48:35
dbId
73843
displayName
5-Phosphoribose 1-diphosphate biosynthesis
edited
[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf
[Pathway:R-HSA-71336] Pentose phosphate pathway - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:14768] 5-phosphoribose 1-diphosphate biosynthetic process
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-111215] D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate - Homo sapiens
[Reaction:R-HSA-73580] D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:111176] Regulation of purine synthesis de novo in human fibroblasts by purine nucleotides and phosphoribosylpyrophosphate
[LiteratureReference:111179] Overexpression of the normal phosphoribosylpyrophosphate synthetase 1 isoform undelies catalytic superactivity of human phosphoribosylpyrophosphate synthetase
[LiteratureReference:111183] Human phosphoribosylpyrophosphate synthetase
[LiteratureReference:111185] Enzymatic synthesis and properties of 5-phosphoribosylpyrophosphate
[LiteratureReference:111189] Human X-linked phosphoribosylpyrophosphate synthetase superactivity is associated with distinct point mutations in the PRPS1 gene
[LiteratureReference:111195] Purification and properties of phosphoribosyl pyrophosphate synthetase from rat liver
[LiteratureReference:111199] Tissue-differential expression of two distinct genes for phosphoribosyl pyrophosphate synthetase and existence of the testic-specific transcript
[LiteratureReference:111205] A human testis-specific mRNA for phosphoribosylpyrophosphate synthetase that initiates from a non-AUG codon
modified
[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name
5-Phosphoribose 1-diphosphate biosynthesis
PRPP biosynthesis
Synthesis of cytosolic 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) from D-ribose 5-phosphate
orthologousEvent
[Pathway:R-PFA-73843] 5-Phosphoribose 1-diphosphate biosynthesis - Plasmodium falciparum
[Pathway:R-SCE-73843] 5-Phosphoribose 1-diphosphate biosynthesis - Saccharomyces cerevisiae
[Pathway:R-SPO-73843] 5-Phosphoribose 1-diphosphate biosynthesis - Schizosaccharomyces pombe
[Pathway:R-DDI-73843] 5-Phosphoribose 1-diphosphate biosynthesis - Dictyostelium discoideum
[Pathway:R-GGA-73843] 5-Phosphoribose 1-diphosphate biosynthesis - Gallus gallus
[Pathway:R-XTR-73843] 5-Phosphoribose 1-diphosphate biosynthesis - Xenopus tropicalis
[Pathway:R-DRE-73843] 5-Phosphoribose 1-diphosphate biosynthesis - Danio rerio
[Pathway:R-SSC-73843] 5-Phosphoribose 1-diphosphate biosynthesis - Sus scrofa
[Pathway:R-BTA-73843] 5-Phosphoribose 1-diphosphate biosynthesis - Bos taurus
[Pathway:R-CFA-73843] 5-Phosphoribose 1-diphosphate biosynthesis - Canis familiaris
[Pathway:R-RNO-73843] 5-Phosphoribose 1-diphosphate biosynthesis - Rattus norvegicus
[Pathway:R-MMU-73843] 5-Phosphoribose 1-diphosphate biosynthesis - Mus musculus
precedingEvent
[Reaction:R-HSA-71306] D-ribulose 5-phosphate <=> ribose 5-phosphate - Homo sapiens
releaseDate
2004-07-06
reviewStatus
[ReviewStatus:9821382] five stars
revised
[InstanceEdit:469644] D'Eustachio, P, 2010-01-24
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-73843
summation
[Summation:111206] 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) is a key inter...
Referrals
(hasEvent)
[Pathway:R-HSA-71336] Pentose phosphate pathway
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