Reactome | PRPS dimers pyrophosphorylate R5P using ATP

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PRPS dimers pyrophosphorylate R5P using ATP Show undefined attributes

catalystActivity	[CatalystActivity:10107230] ribose phosphate diphosphokinase activity of PRPS dimers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10107232
displayName	PRPS dimers pyrophosphorylate R5P using ATP
eventOf	[Pathway:R-RNO-73843] 5-Phosphoribose 1-diphosphate biosynthesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Rattus norvegicus [Reaction:R-RNO-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-73580] PRPS dimers pyrophosphorylate R5P using ATP - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-73578] R5P [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PRPS dimers pyrophosphorylate R5P using ATP D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate addition of diphosphate (PP) to ribose 5-phosphate to form 5'-Phospho-alpha-D-ribose 1-diphosphate (PRPP)
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73566] PRPP [cytosol]
precedingEvent	[Reaction:R-RNO-71306] RPIA isomerizes D-ribulose 5-phosphate to ribose 5-phosphate - Rattus norvegicus
regulatedBy	[Requirement:R-HSA-9034457] Requirement by 'Mg2+ [cytosol]' [Requirement:R-HSA-9034462] Requirement by 'Pi [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-73580
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-RNO-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP [Reaction:R-RNO-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate
(hasEvent)	[Pathway:R-RNO-73843] 5-Phosphoribose 1-diphosphate biosynthesis
(inferredTo)	[Reaction:R-HSA-73580] PRPS dimers pyrophosphorylate R5P using ATP

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