Reactome | CAD hexamer transforms L-Gln to CAP

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CAD hexamer transforms L-Gln to CAP Show undefined attributes

authored	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
catalystActivity	[CatalystActivity:73458] carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity of CAD hexamer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:12668043] RHEA:18634 [DatabaseIdentifier:9975779] RHEA:18634
dbId	73577
displayName	CAD hexamer transforms L-Gln to CAP
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-500753] Pyrimidine biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-73573] CAD hexamer transforms CAP to N-carb-L-Asp - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-111627] HCO3- [cytosol] [SimpleEntity:R-ALL-29472] L-Gln [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111631] Control of pyrimidine biosynthesis in human lymphocytes. Simultaneous increase in activities of glutamine-utilizing carbamyl phosphate synthetase and aspartate transcarbamylase in phytohemagglutinin-stimulated human peripheral lymphocytes and their enzyme co-purification [LiteratureReference:111634] Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	CAD hexamer transforms L-Gln to CAP hydrogencarbonate + L-glutamine + 2 ATP + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+) L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate bicarbonate and glutamine combine to form carbamoyl phosphate
orthologousEvent	[Reaction:R-GGA-419440] L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate - Gallus gallus [Reaction:R-MMU-73577] CAD hexamer transforms L-Gln to CAP - Mus musculus [Reaction:R-PFA-73577] CAD hexamer transforms L-Gln to CAP - Plasmodium falciparum [Reaction:R-SCE-73577] CAD hexamer transforms L-Gln to CAP - Saccharomyces cerevisiae [Reaction:R-SPO-73577] CAD hexamer transforms L-Gln to CAP - Schizosaccharomyces pombe [Reaction:R-DDI-73577] CAD hexamer transforms L-Gln to CAP - Dictyostelium discoideum [Reaction:R-CEL-73577] CAD hexamer transforms L-Gln to CAP - Caenorhabditis elegans [Reaction:R-DME-73577] CAD hexamer transforms L-Gln to CAP - Drosophila melanogaster [Reaction:R-GGA-73577] CAD hexamer transforms L-Gln to CAP - Gallus gallus [Reaction:R-XTR-73577] CAD hexamer transforms L-Gln to CAP - Xenopus tropicalis [Reaction:R-SSC-73577] CAD hexamer transforms L-Gln to CAP - Sus scrofa [Reaction:R-BTA-73577] CAD hexamer transforms L-Gln to CAP - Bos taurus [Reaction:R-CFA-73577] CAD hexamer transforms L-Gln to CAP - Canis familiaris [Reaction:R-RNO-73577] CAD hexamer transforms L-Gln to CAP - Rattus norvegicus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-111647] CAP [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73577
summation	[Summation:111630] The synthesis of carbamoyl phosphate from glutamine, bicarbo...
updateTrackers	[UpdateTracker:9776007] Update Tracker - [Reaction:73577] CAD hexamer transforms L-Gln to CAP - v78:[addOutput] [UpdateTracker:9791542] Update Tracker - [Reaction:73577] CAD hexamer transforms L-Gln to CAP - v29:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776007] Update Tracker - [Reaction:73577] CAD hexamer transforms L-Gln to CAP - v78:[addOutput] [UpdateTracker:9791542] Update Tracker - [Reaction:73577] CAD hexamer transforms L-Gln to CAP - v29:[modifyText]
(hasEvent)	[Pathway:R-HSA-500753] Pyrimidine biosynthesis
(precedingEvent)	[Reaction:R-HSA-73573] CAD hexamer transforms CAP to N-carb-L-Asp