The synthesis of carbamoyl phosphate from glutamine, bicarbo...

created [InstanceEdit:73844] 2007-03-03 09:38:00
dbId 111630
displayName The synthesis of carbamoyl phosphate from glutamine, bicarbo...
modified [InstanceEdit:419505] D'Eustachio, P, 2009-05-01 21:46:52
schemaClass Summation
text The synthesis of carbamoyl phosphate from glutamine, bicarbonate, and ATP is catalyzed by the carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity of cytosolic trifunctional CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) protein (Ito and Uchino 1973; Iwahana et al. 1996). The purified human protein is active in several different oligomerization states, as is its Syrian hamster homologue. The most abundant form of the latter is a hexamer, and the active human protein is annotated as a hexamer by inference (Ito and Uchino 1973; Lee et al. 1985).
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