Reactome | CAD hexamer transforms L-Gln to CAP

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CAD hexamer transforms L-Gln to CAP Show undefined attributes

catalystActivity	[CatalystActivity:11082804] carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity of CAD hexamer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11082806
displayName	CAD hexamer transforms L-Gln to CAP
eventOf	[Pathway:R-SCE-500753] Pyrimidine biosynthesis - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-73573] CAD hexamer transforms CAP to N-carb-L-Asp - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-73577] CAD hexamer transforms L-Gln to CAP - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-111627] HCO3- [cytosol] [SimpleEntity:R-ALL-29472] L-Gln [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CAD hexamer transforms L-Gln to CAP hydrogencarbonate + L-glutamine + 2 ATP + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+) L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate bicarbonate and glutamine combine to form carbamoyl phosphate
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-111647] CAP [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-73577
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-500753] Pyrimidine biosynthesis
(precedingEvent)	[Reaction:R-SCE-73573] CAD hexamer transforms CAP to N-carb-L-Asp
(inferredTo)	[Reaction:R-HSA-73577] CAD hexamer transforms L-Gln to CAP

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