Reactome | Formation of eIF2:GDP:eIF2B intermediate

Schema > Reaction > Entries

Formation of eIF2:GDP:eIF2B intermediate Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
dbId	72670
displayName	Formation of eIF2:GDP:eIF2B intermediate
eventOf	[Pathway:R-HSA-72731] Recycling of eIF2:GDP - Homo sapiens
followingEvent	[Reaction:R-HSA-72722] eIF2 activation - Homo sapiens
input	[Complex:R-HSA-72530] eIF2:GDP [cytosol] [Complex:R-HSA-72526] eIF2B subunits complex [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:72723] The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2 [LiteratureReference:72727] Mechanism of the nucleotide exchange reaction in eukaryotic polypeptide chain initiation. Characterization of the guanine nucleotide exchange factor as a GTP-binding protein
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Formation of eIF2:GDP:eIF2B intermediate
orthologousEvent	[Reaction:R-RNO-72670] Formation of eIF2:GDP:eIF2B intermediate - Rattus norvegicus [Reaction:R-PFA-72670] Formation of eIF2:GDP:eIF2B intermediate - Plasmodium falciparum [Reaction:R-SCE-72670] Formation of eIF2:GDP:eIF2B intermediate - Saccharomyces cerevisiae [Reaction:R-SPO-72670] Formation of eIF2:GDP:eIF2B intermediate - Schizosaccharomyces pombe [Reaction:R-DDI-72670] Formation of eIF2:GDP:eIF2B intermediate - Dictyostelium discoideum [Reaction:R-CEL-72670] Formation of eIF2:GDP:eIF2B intermediate - Caenorhabditis elegans [Reaction:R-DME-72670] Formation of eIF2:GDP:eIF2B intermediate - Drosophila melanogaster [Reaction:R-GGA-72670] Formation of eIF2:GDP:eIF2B intermediate - Gallus gallus [Reaction:R-DRE-72670] Formation of eIF2:GDP:eIF2B intermediate - Danio rerio [Reaction:R-SSC-72670] Formation of eIF2:GDP:eIF2B intermediate - Sus scrofa [Reaction:R-BTA-72670] Formation of eIF2:GDP:eIF2B intermediate - Bos taurus [Reaction:R-CFA-72670] Formation of eIF2:GDP:eIF2B intermediate - Canis familiaris [Reaction:R-MMU-72670] Formation of eIF2:GDP:eIF2B intermediate - Mus musculus
output	[Complex:R-HSA-72529] eIF2:GDP: eIF2B [cytosol]
precedingEvent	[Reaction:R-HSA-72619] eIF2:GTP is hydrolyzed, eIFs are released - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-72670
summation	[Summation:72741] Inactive eIF2:GDP binds eIF2B to form an eIF2:GDP:eIF2B inte...

Referrals

(hasEvent)	[Pathway:R-HSA-72731] Recycling of eIF2:GDP
(precedingEvent)	[Reaction:R-HSA-72722] eIF2 activation