Reactome | eIF2 activation

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eIF2 activation Show undefined attributes

catalystActivity	[CatalystActivity:10229950] translation initiation factor activity of eIF2B subunits complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10229952
displayName	eIF2 activation
eventOf	[Pathway:R-CFA-72731] Recycling of eIF2:GDP - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Canis familiaris
inferredFrom	[Reaction:R-HSA-72722] eIF2 activation - Homo sapiens
input	[Complex:R-CFA-72529] eIF2:GDP: eIF2B [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	eIF2 activation
output	[Complex:R-CFA-72531] eIF2:GTP [cytosol] [Complex:R-CFA-72526] eIF2B subunits complex [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol]
precedingEvent	[Reaction:R-CFA-72670] Formation of eIF2:GDP:eIF2B intermediate - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-72722
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-72731] Recycling of eIF2:GDP
(precedingEvent)	[Reaction:R-CFA-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex
(inferredTo)	[Reaction:R-HSA-72722] eIF2 activation