Reactome | Start codon recognition

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Start codon recognition Show undefined attributes

catalystActivity	[CatalystActivity:72620] translation initiation factor activity of eIF1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:72607] Merrick, WC, 2002-12-16 00:00:00
dbId	72697
displayName	Start codon recognition
eventOf	[Pathway:R-HSA-72702] Ribosomal scanning and start codon recognition - Homo sapiens
followingEvent	[Reaction:R-HSA-72619] eIF2:GTP is hydrolyzed, eIFs are released - Homo sapiens
input	[Complex:R-HSA-72594] 48S complex [cytosol] [OtherEntity:R-ALL-72617] eIF1 [cytosol] [EntityWithAccessionedSequence:R-HSA-72557] EIF1AX [cytosol] [Complex:R-HSA-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] [EntityWithAccessionedSequence:R-HSA-72616] EIF5 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:72657] Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons [Book:72698] 9780879696184 Genetic approaches to translation initiation in Saccharomyces cerevisiae. Translational Control of Gene Expression Sonenberg, Nahum
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Start codon recognition
orthologousEvent	[Reaction:R-PFA-72697] Start codon recognition - Plasmodium falciparum [Reaction:R-SCE-72697] Start codon recognition - Saccharomyces cerevisiae [Reaction:R-SPO-72697] Start codon recognition - Schizosaccharomyces pombe [Reaction:R-DDI-72697] Start codon recognition - Dictyostelium discoideum [Reaction:R-CEL-72697] Start codon recognition - Caenorhabditis elegans [Reaction:R-DME-72697] Start codon recognition - Drosophila melanogaster [Reaction:R-GGA-72697] Start codon recognition - Gallus gallus [Reaction:R-DRE-72697] Start codon recognition - Danio rerio [Reaction:R-SSC-72697] Start codon recognition - Sus scrofa [Reaction:R-BTA-72697] Start codon recognition - Bos taurus [Reaction:R-CFA-72697] Start codon recognition - Canis familiaris [Reaction:R-RNO-72697] Start codon recognition - Rattus norvegicus [Reaction:R-MMU-72697] Start codon recognition - Mus musculus
output	[Complex:R-HSA-72594] 48S complex [cytosol] [OtherEntity:R-ALL-72617] eIF1 [cytosol] [EntityWithAccessionedSequence:R-HSA-72557] EIF1AX [cytosol] [Complex:R-HSA-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] [EntityWithAccessionedSequence:R-HSA-72616] EIF5 [cytosol]
precedingEvent	[Reaction:R-HSA-72621] Ribosomal scanning - Homo sapiens
releaseDate	2004-07-06
requiredInputComponent	[OtherEntity:R-ALL-72700] AUG start codon [nucleoplasm]
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-72697
summation	[Summation:72701] The AUG initiation codon in the mRNA is recognized by base p...

Referrals

(hasEvent)	[Pathway:R-HSA-72702] Ribosomal scanning and start codon recognition
(precedingEvent)	[Reaction:R-HSA-72619] eIF2:GTP is hydrolyzed, eIFs are released

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