Start codon recognition

Stable Identifier
R-HSA-72697
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Start codon recognition
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The AUG initiation codon in the mRNA is recognized by base pairing with the anticodon of the Met-tRNAi. This reaction requires eIF1, eIF1A, eIF2 and eIF5.
Literature References
PubMed ID Title Journal Year
  Translational Control of Gene Expression

Sonenberg, N, Hershey, JW, Mathews, MB

  2001
9732867 Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons.

Pestova, TV, Borukhov, SI, Hellen, CU

Nature 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

translation initiation factor activity of eIF1 [cytosol]

Physical Entity
eIF1 [cytosol]
Activity
translation initiation factor activity (GO:0003743)
Orthologous Events
Start codon recognition (Bos taurus)
Start codon recognition (Caenorhabditis elegans)
Start codon recognition (Canis familiaris)
Start codon recognition (Danio rerio)
Start codon recognition (Dictyostelium discoideum)
Start codon recognition (Drosophila melanogaster)
Start codon recognition (Gallus gallus)
Start codon recognition (Mus musculus)
Start codon recognition (Plasmodium falciparum)
Start codon recognition (Rattus norvegicus)
Start codon recognition (Saccharomyces cerevisiae)
Start codon recognition (Schizosaccharomyces pombe)
Start codon recognition (Sus scrofa)
Start codon recognition (Xenopus tropicalis)
Created
Merrick, WC  (2002-12-16)
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