Reactome | EIF2S1:EIF2S2:EIF2S3 [cytosol]

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EIF2S1:EIF2S2:EIF2S3 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-5226905] ABCF1:EIF2S1:EIF2S2:EIF2S3 [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9648888] p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) - Homo sapiens [Reaction:R-HSA-9633008] p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 - Homo sapiens [BlackBoxEvent:R-HSA-9840415] DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) - Homo sapiens [Reaction:R-HSA-72663] De novo formation of eIF2:GTP - Homo sapiens [Reaction:R-HSA-5227009] ABCF1 binds EIF2 - Homo sapiens [Reaction:R-HSA-381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK - Homo sapiens [Reaction:R-HSA-9835885] p-PKR dimer phosphorylates eIF2-alpha - Homo sapiens [Reaction:R-HSA-72697] Start codon recognition - Homo sapiens
crossReference	[DatabaseIdentifier:11891787] ComplexPortal:CPX-2716
dbId	72515
displayName	EIF2S1:EIF2S2:EIF2S3 [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-HSA-72510] EIF2S1 [cytosol] [EntityWithAccessionedSequence:R-HSA-72512] EIF2S2 [cytosol] [EntityWithAccessionedSequence:R-HSA-72514] EIF2S3 [cytosol]
inDisease	false
inferredTo	[Complex:R-MMU-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] - Mus musculus [Complex:R-RNO-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] - Rattus norvegicus [Complex:R-CFA-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] - Canis familiaris [Complex:R-BTA-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] - Bos taurus [Complex:R-SSC-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] - Sus scrofa [Complex:R-DRE-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] - Danio rerio [Complex:R-XTR-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] - Xenopus tropicalis [Complex:R-GGA-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] - Gallus gallus [Complex:R-DME-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] - Drosophila melanogaster [Complex:R-CEL-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] - Caenorhabditis elegans [Complex:R-DDI-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] - Dictyostelium discoideum [Complex:R-SPO-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] - Schizosaccharomyces pombe [Complex:R-SCE-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] - Saccharomyces cerevisiae [Complex:R-PFA-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] - Plasmodium falciparum
modified	[InstanceEdit:11891188] Wright, Adam, 2024-03-11
name	EIF2S1:EIF2S2:EIF2S3 eIF2 subunit complex MP
producedByEvent	[Reaction:R-HSA-72697] Start codon recognition - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-72515

Referrals

(hasComponent)	[Complex:R-HSA-5226905] ABCF1:EIF2S1:EIF2S2:EIF2S3 [cytosol] [Complex:R-HSA-72529] eIF2:GDP: eIF2B [cytosol] [Complex:R-HSA-72530] eIF2:GDP [cytosol] [Complex:R-HSA-72531] eIF2:GTP [cytosol]
(input)	[Reaction:R-HSA-5227009] ABCF1 binds EIF2 [Reaction:R-HSA-9648888] p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) [Reaction:R-HSA-381111] EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK [Reaction:R-HSA-9633008] p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 [BlackBoxEvent:R-HSA-9840415] DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha) [Reaction:R-HSA-72663] De novo formation of eIF2:GTP [Reaction:R-HSA-72697] Start codon recognition [Reaction:R-HSA-9835885] p-PKR dimer phosphorylates eIF2-alpha
(output)	[Reaction:R-HSA-72697] Start codon recognition

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