Reactome | Ribosomal scanning

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Ribosomal scanning Show undefined attributes

catalystActivity	[CatalystActivity:72620] translation initiation factor activity of eIF1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:72607] Merrick, WC, 2002-12-16 00:00:00
dbId	72621
displayName	Ribosomal scanning
eventOf	[Pathway:R-HSA-72702] Ribosomal scanning and start codon recognition - Homo sapiens
followingEvent	[Reaction:R-HSA-72697] Start codon recognition - Homo sapiens
input	[Complex:R-HSA-72592] 43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:72704] Evaluation of the "scanning model" for initiation of protein synthesis in eucaryotes [LiteratureReference:72650] The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes [LiteratureReference:72652] Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors [LiteratureReference:72744] Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes [LiteratureReference:72746] Requirement of the DEAD-Box protein ded1p for messenger RNA translation. [LiteratureReference:72750] Ded1p, a DEAD-box protein required for translation initiation in Saccharomyces cerevisiae, is an RNA helicase
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	Ribosomal scanning
orthologousEvent	[Reaction:R-MMU-72621] Ribosomal scanning - Mus musculus [Reaction:R-PFA-72621] Ribosomal scanning - Plasmodium falciparum [Reaction:R-SCE-72621] Ribosomal scanning - Saccharomyces cerevisiae [Reaction:R-SPO-72621] Ribosomal scanning - Schizosaccharomyces pombe [Reaction:R-DDI-72621] Ribosomal scanning - Dictyostelium discoideum [Reaction:R-CEL-72621] Ribosomal scanning - Caenorhabditis elegans [Reaction:R-DME-72621] Ribosomal scanning - Drosophila melanogaster [Reaction:R-GGA-72621] Ribosomal scanning - Gallus gallus [Reaction:R-XTR-72621] Ribosomal scanning - Xenopus tropicalis [Reaction:R-DRE-72621] Ribosomal scanning - Danio rerio [Reaction:R-SSC-72621] Ribosomal scanning - Sus scrofa [Reaction:R-BTA-72621] Ribosomal scanning - Bos taurus [Reaction:R-CFA-72621] Ribosomal scanning - Canis familiaris [Reaction:R-RNO-72621] Ribosomal scanning - Rattus norvegicus
output	[Complex:R-HSA-72594] 48S complex [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-157849] Formation of translation initiation complexes containing mRNA that does not circularize - Homo sapiens
regulatedBy	[Requirement:R-HSA-72781] Requirement by 'ATP [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-72621
summation	[Summation:72755] The mRNA-bound ribosomal complex moves along the 5'-untransl...

Referrals

(hasEvent)	[Pathway:R-HSA-72702] Ribosomal scanning and start codon recognition
(precedingEvent)	[Reaction:R-HSA-72697] Start codon recognition

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