Reactome | Start codon recognition

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Start codon recognition Show undefined attributes

catalystActivity	[CatalystActivity:72620] translation initiation factor activity of eIF1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10229949
displayName	Start codon recognition
eventOf	[Pathway:R-CFA-72702] Ribosomal scanning and start codon recognition - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-72619] eIF2:GTP is hydrolyzed, eIFs are released - Canis familiaris
inferredFrom	[Reaction:R-HSA-72697] Start codon recognition - Homo sapiens
input	[Complex:R-CFA-72594] 48S complex [cytosol] [OtherEntity:R-ALL-72617] eIF1 [cytosol] [Complex:R-CFA-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] [EntityWithAccessionedSequence:R-CFA-72616] EIF5 [cytosol] [EntityWithAccessionedSequence:R-CFA-72557] LOC119868752 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Start codon recognition
output	[Complex:R-CFA-72594] 48S complex [cytosol] [OtherEntity:R-ALL-72617] eIF1 [cytosol] [Complex:R-CFA-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] [EntityWithAccessionedSequence:R-CFA-72616] EIF5 [cytosol] [EntityWithAccessionedSequence:R-CFA-72557] LOC119868752 [cytosol]
precedingEvent	[Reaction:R-CFA-72621] Ribosomal scanning - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-72697
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-72702] Ribosomal scanning and start codon recognition
(precedingEvent)	[Reaction:R-CFA-72619] eIF2:GTP is hydrolyzed, eIFs are released
(inferredTo)	[Reaction:R-HSA-72697] Start codon recognition