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De novo formation of eIF2:GTP
Stable Identifier
R-HSA-72663
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
De novo formation of eIF2:GTP (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activation of eIF2 through direct binding of GTP.
Participants
Input
EIF2S1:EIF2S2:EIF2S3 [cytosol]
(Homo sapiens)
GTP [cytosol]
Output
eIF2:GTP [cytosol]
(Homo sapiens)
Participates
as an event of
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
Orthologous Events
De novo formation of eIF2:GTP (Bos taurus)
De novo formation of eIF2:GTP (Caenorhabditis elegans)
De novo formation of eIF2:GTP (Canis familiaris)
De novo formation of eIF2:GTP (Danio rerio)
De novo formation of eIF2:GTP (Dictyostelium discoideum)
De novo formation of eIF2:GTP (Drosophila melanogaster)
De novo formation of eIF2:GTP (Gallus gallus)
De novo formation of eIF2:GTP (Mus musculus)
De novo formation of eIF2:GTP (Plasmodium falciparum)
De novo formation of eIF2:GTP (Rattus norvegicus)
De novo formation of eIF2:GTP (Saccharomyces cerevisiae)
De novo formation of eIF2:GTP (Schizosaccharomyces pombe)
De novo formation of eIF2:GTP (Sus scrofa)
De novo formation of eIF2:GTP (Xenopus tropicalis)
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