Reactome | De novo formation of eIF2:GTP

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10562878
displayName	De novo formation of eIF2:GTP
eventOf	[Pathway:R-DRE-72695] Formation of the ternary complex, and subsequently, the 43S complex - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex - Danio rerio
inferredFrom	[Reaction:R-HSA-72663] De novo formation of eIF2:GTP - Homo sapiens
input	[Complex:R-DRE-72515] EIF2S1:EIF2S2:EIF2S3 [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	De novo formation of eIF2:GTP
output	[Complex:R-DRE-72531] eIF2:GTP [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-72663
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-72695] Formation of the ternary complex, and subsequently, the 43S complex
(precedingEvent)	[Reaction:R-DRE-72669] Met-tRNAi binds to eIF2:GTP to form the ternary complex
(inferredTo)	[Reaction:R-HSA-72663] De novo formation of eIF2:GTP

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