Reactome | glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+

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glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ Show undefined attributes

catalystActivity	[CatalystActivity:10105695] glutathione-disulfide reductase (NADPH) activity of GSR-2:FAD dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10105697
displayName	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
eventOf	[Pathway:R-RNO-5628897] TP53 Regulates Metabolic Genes - Rattus norvegicus [Pathway:R-RNO-3299685] Detoxification of Reactive Oxygen Species - Rattus norvegicus [Pathway:R-RNO-499943] Interconversion of nucleotide di- and triphosphates - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Homo sapiens
input	[SimpleEntity:R-ALL-111745] GSSG [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ glutathione disulfide + NADPH + H(+) => 2 glutathione + NADP(+)
output	2 × [SimpleEntity:R-ALL-29450] GSH [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-RNO-71299] PGD decarboxylates 6-phospho-D-gluconate - Rattus norvegicus [Reaction:R-RNO-70377] G6PD multimers dehydrogenate G6P - Rattus norvegicus [Reaction:R-RNO-111746] glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) - Rattus norvegicus [Reaction:R-RNO-198813] GSTO dimers reduce DeHA to AscH- - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-71682
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-499943] Interconversion of nucleotide di- and triphosphates [Pathway:R-RNO-5628897] TP53 Regulates Metabolic Genes [Pathway:R-RNO-3299685] Detoxification of Reactive Oxygen Species
(precedingEvent)	[Reaction:R-RNO-71676] GPX1 catalyzes reaction of reduced glutathione and H2O2 to form oxidized glutathione and H2O
(inferredTo)	[Reaction:R-HSA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+

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