Cytosolic glutathione reductase catalyzes the reaction of glutathione (oxidized) and NADPH + H+ to form two molecules of glutathione (reduced) and NADP+ (Scott et al. 1963, Loos et al. 1976). Deficiency of glutathione reductase can cause hemolytic anemia.
Roos, D, Houwerzijl, J, Weening, R, Loos, H
EKSTRAND, V, SCOTT, EM, DUNCAN, IW
glutathione-disulfide reductase (NADPH) activity of GSR-2:FAD dimer [cytosol]
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