glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+

Stable Identifier
R-HSA-71682
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cytosolic glutathione reductase catalyzes the reaction of glutathione (oxidized) and NADPH + H+ to form two molecules of glutathione (reduced) and NADP+ (Scott et al. 1963, Loos et al. 1976). Deficiency of glutathione reductase can cause hemolytic anemia.
Literature References
PubMed ID Title Journal Year
947404 Familial deficiency of glutathione reductase in human blood cells

Loos, H, Roos, D, Weening, R, Houwerzijl, J

Blood 1976
14086726 PURIFICATION AND PROPERTIES OF GLUTATHIONE REDUCTASE OF HUMAN ERYTHROCYTES

SCOTT, EM, DUNCAN, IW, EKSTRAND, V

J. Biol. Chem. 1963
Participants
Input
Output
Participates
as an event of
Catalyst Activity

glutathione-disulfide reductase (NADPH) activity of GSR-2:FAD dimer [cytosol]

Physical Entity
GSR-2:FAD dimer [cytosol] (Homo sapiens)
Activity
glutathione-disulfide reductase (NADPH) activity (GO:0004362)
Orthologous Events
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Bos taurus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Caenorhabditis elegans)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Canis familiaris)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Dictyostelium discoideum)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Gallus gallus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Mus musculus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Plasmodium falciparum)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Rattus norvegicus)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Saccharomyces cerevisiae)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Schizosaccharomyces pombe)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Sus scrofa)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2004-03-17)
Reviewed
Inga, A  (2016-02-04)
Zaccara, S  (2016-02-04)
Cite Us!