Reactome | glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+

Schema > Reaction > Entries

glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ Show undefined attributes

catalystActivity	[CatalystActivity:10998992] glutathione-disulfide reductase (NADPH) activity of GSR-2:FAD dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	10998994
displayName	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
eventOf	[Pathway:R-DDI-5628897] TP53 Regulates Metabolic Genes - Dictyostelium discoideum [Pathway:R-DDI-3299685] Detoxification of Reactive Oxygen Species - Dictyostelium discoideum [Pathway:R-DDI-499943] Interconversion of nucleotide di- and triphosphates - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Homo sapiens
input	[SimpleEntity:R-ALL-111745] GSSG [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ glutathione disulfide + NADPH + H(+) => 2 glutathione + NADP(+)
output	2 × [SimpleEntity:R-ALL-29450] GSH [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-DDI-71299] PGD decarboxylates 6-phospho-D-gluconate - Dictyostelium discoideum [Reaction:R-DDI-70377] G6PD multimers dehydrogenate G6P - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-71682
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-5628897] TP53 Regulates Metabolic Genes [Pathway:R-DDI-499943] Interconversion of nucleotide di- and triphosphates [Pathway:R-DDI-3299685] Detoxification of Reactive Oxygen Species
(inferredTo)	[Reaction:R-HSA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+

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