kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O

Stable Identifier
R-HSA-71200
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
H(+) + L-kynurenine + NADPH + O2 => 3-hydroxy-L-kynurenine + H2O + NADP(+)
ReviewStatus
5/5
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kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cytosolic kynurenine 3-monooxygenase catalyzes the reaction of L-kynurenine, NADPH + H+, and O2 to form 3-hydroxy-L-kynurenine, NADP+, and H2O.
Literature References
PubMed ID Title Journal Year
10672018 Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

Breton, J, Avanzi, N, Magagnin, S, Covini, N, Magistrelli, G, Cozzi, L, Isacchi, A

Eur J Biochem 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

kynurenine 3-monooxygenase activity of KMO [cytosol]

Physical Entity
KMO [cytosol] (Homo sapiens)
Activity
kynurenine 3-monooxygenase activity (GO:0004502)
Orthologous Events
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Bos taurus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Caenorhabditis elegans)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Canis familiaris)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Danio rerio)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Dictyostelium discoideum)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Drosophila melanogaster)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Gallus gallus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Mus musculus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Rattus norvegicus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Saccharomyces cerevisiae)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Sus scrofa)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Xenopus tropicalis)
Cross References
RHEA
Rhea
Authored
D'Eustachio, P  (2005-07-20)
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