kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O

Stable Identifier
R-HSA-71200
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic kynurenine 3-monooxygenase catalyzes the reaction of L-kynurenine, NADPH + H+, and O2 to form 3-hydroxy-L-kynurenine, NADP+, and H2O.

Literature References
PubMed ID Title Journal Year
10672018 Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

Covini, N, Avanzi, N, Cozzi, L, Magagnin, S, Breton, J, Isacchi, A, Magistrelli, G

Eur J Biochem 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

kynurenine 3-monooxygenase activity of KMO [cytosol]

Physical Entity
KMO [cytosol] (Homo sapiens)
Activity
kynurenine 3-monooxygenase activity (GO:0004502)
Orthologous Events
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Bos taurus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Caenorhabditis elegans)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Canis familiaris)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Danio rerio)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Dictyostelium discoideum)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Drosophila melanogaster)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Gallus gallus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Mus musculus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Rattus norvegicus)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Saccharomyces cerevisiae)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Sus scrofa)
kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2005-07-20)
Cite Us!