kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O

Stable Identifier
R-HSA-71200
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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Cytosolic kynurenine 3-monooxygenase catalyzes the reaction of L-kynurenine, NADPH + H+, and O2 to form 3-hydroxy-L-kynurenine, NADP+, and H2O.

Literature References
PubMed ID Title Journal Year
10672018 Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

Breton, J, Avanzi, N, Magagnin, S, Covini, N, Magistrelli, G, Cozzi, L, Isacchi, A

Eur J Biochem 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
kynurenine 3-monooxygenase activity of KMO [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored