Reactome | ACO2 isomerizes citrate

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ACO2 isomerizes citrate Show undefined attributes

catalystActivity	[CatalystActivity:70969] aconitate hydratase activity of ACO2:4Fe-4S [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643553] aconitate hydratase activity of ACO2:4Fe-4S [mitochondrial matrix] Aconitase polymorphism in man
category	transition
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:12667541] RHEA:10337 [DatabaseIdentifier:9854185] RHEA:10336
dbId	70971
deleted	[Deleted:451030] Deletion of instance: 70970
displayName	ACO2 isomerizes citrate
eventOf	[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle) - Homo sapiens
followingEvent	[Reaction:R-HSA-450984] IDH2 dimer decarboxylates isocitrate - Homo sapiens [Reaction:R-HSA-70967] IDH3 complex decarboxylates isocitrate - Homo sapiens
input	[SimpleEntity:R-ALL-29654] CIT [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:198411] Purification and partial amino acid sequence of human aconitase [LiteratureReference:450996] Aconitase polymorphism in man [LiteratureReference:9853614] ACO2 clinicobiological dataset with extensive phenotype ontology annotation
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	ACO2 isomerizes citrate citrate => D-threo-isocitrate
orthologousEvent	[Reaction:R-MMU-70971] ACO2 isomerizes citrate - Mus musculus [Reaction:R-RNO-70971] ACO2 isomerizes citrate - Rattus norvegicus [Reaction:R-CFA-70971] ACO2 isomerizes citrate - Canis familiaris [Reaction:R-BTA-70971] ACO2 isomerizes citrate - Bos taurus [Reaction:R-DRE-70971] ACO2 isomerizes citrate - Danio rerio [Reaction:R-SCE-70971] ACO2 isomerizes citrate - Saccharomyces cerevisiae [Reaction:R-SPO-70971] ACO2 isomerizes citrate - Schizosaccharomyces pombe [Reaction:R-GGA-70971] ACO2 isomerizes citrate - Gallus gallus [Reaction:R-DDI-70971] ACO2 isomerizes citrate - Dictyostelium discoideum [Reaction:R-CEL-70971] ACO2 isomerizes citrate - Caenorhabditis elegans [Reaction:R-XTR-70971] ACO2 isomerizes citrate - Xenopus tropicalis [Reaction:R-SSC-70971] ACO2 isomerizes citrate - Sus scrofa [Reaction:R-DME-70971] ACO2 isomerizes citrate - Drosophila melanogaster
output	[SimpleEntity:R-ALL-29938] ISCIT [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-70975] CS acetylates OA to citrate - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
regulatedBy	[NegativeRegulation:9855647] Negative regulation by 'ACO2:3Fe-4S [mitochondrial matrix]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15
revised	[InstanceEdit:451045] D'Eustachio, P, 2009-12-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70971
summation	[Summation:71415] Mitochondrial aconitase (ACO2) reversibly converts citrate t...
updateTrackers	[UpdateTracker:9864269] Update Tracker - [Reaction:70971] ACO2 isomerizes citrate - v88:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9791193] Update Tracker - [Reaction:70971] citrate <=> isocitrate - v32:[addLiteratureReference, add_removeOutput, modifyText] [UpdateTracker:9792323] Update Tracker - [Reaction:70971] citrate <=> isocitrate - v22:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9864269] Update Tracker - [Reaction:70971] ACO2 isomerizes citrate - v88:[addLiteratureReference, addRegulator, modifyText] [UpdateTracker:9791193] Update Tracker - [Reaction:70971] citrate <=> isocitrate - v32:[addLiteratureReference, add_removeOutput, modifyText] [UpdateTracker:9792323] Update Tracker - [Reaction:70971] citrate <=> isocitrate - v22:[addLiteratureReference, modifyText]
(replacementInstances)	[Deleted:451030] Deletion of instance: 70970
(hasEvent)	[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle)
(precedingEvent)	[Reaction:R-HSA-450984] IDH2 dimer decarboxylates isocitrate [Reaction:R-HSA-70967] IDH3 complex decarboxylates isocitrate

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