citrate <=> isocitrate

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mitochondrial aconitase reversibly converts citrate to isocitrate via a cis-aconitate intermediate. Mitochondrial aconitase activity has been demonstrated in diverse human tissue extracts (Slaughter et al. 1975) and a protein homologous to the well-characterized porcine enzyme has been purified from human tissues (Baldwin et al. 1991).

Literature References
PubMed ID Title Journal Year
1052766 Aconitase polymorphism in man

Slaughter, CA, Hopkinson, DA, Harris, H

Ann Hum Genet 1975
1946331 Purification and partial amino acid sequence of human aconitase

Baldwin, GS, Seet, KL, Callaghan, J, Toncich, G, Toh, BH, Moritz, RL, Rubira, MR, Simpson, R

Protein Seq Data Anal 1991
Participant Of
Catalyst Activity
Catalyst Activity
aconitate hydratase activity of ACO2 [mitochondrial matrix]
Physical Entity
Orthologous Events