Reactome | saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+

saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+

Stable Identifier

R-HSA-70940

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

H2O + L-saccharopine + NAD(+) => (S)-2-amino-6-oxohexanoate + H(+) + L-glutamate + NADH, AASS tetramer oxidises SACN to 2AMAS

ReviewStatus

5/5

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saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+

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The saccharopine dehydrogenase activity of lysine-ketoglutarate reductase / saccharopine dehydrogenase homotetramer in the mitochondrial matrix catalyzes the reaction of saccharopine (N6-(L-1,3-Dicarboxypropyl)-L-lysine), H2O, and NAD+ to form 'L-2-Aminoadipate 6-semialdehyde, glutamate, and NADH + H+ (Markovitz et al. 1984; Sacksteder et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
6434529	Familial hyperlysinemias. Purification and characterization of the bifunctional aminoadipic semialdehyde synthase with lysine-ketoglutarate reductase and saccharopine dehydrogenase activities. Markovitz, PJ, Chuang, DT, Cox, RP	J Biol Chem	1984
10775527	Identification of the alpha-aminoadipic semialdehyde synthase gene, which is defective in familial hyperlysinemia. Biery, BJ, Goodman, BK, Geraghty, MT, Geisbrecht, BV, Gould, SJ, Sacksteder, KA, Morrell, JC, Cox, RP	Am J Hum Genet	2001