Reactome | G6PD multimers dehydrogenate G6P

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G6PD multimers dehydrogenate G6P Show undefined attributes

catalystActivity	[CatalystActivity:10227699] glucose-6-phosphate dehydrogenase activity of G6PD dimer and tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10227701
displayName	G6PD multimers dehydrogenate G6P
eventOf	[Pathway:R-CFA-71336] Pentose phosphate pathway - Canis familiaris [Pathway:R-CFA-5628897] TP53 Regulates Metabolic Genes - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-71296] PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphate - Canis familiaris [Reaction:R-CFA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Canis familiaris
inferredFrom	[Reaction:R-HSA-70377] G6PD multimers dehydrogenate G6P - Homo sapiens
input	[SimpleEntity:R-ALL-30537] G6P [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	G6PD multimers dehydrogenate G6P alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+ D-glucose 6-phosphate + NADP(+) => 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH
output	[SimpleEntity:R-ALL-31467] D-Glucono-1,5-lactone 6-phosphate [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
precedingEvent	[Reaction:R-CFA-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Canis familiaris [Reaction:R-CFA-70475] GPI dimer isomerizes Fru(6)P to G6P - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-70377
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5628897] TP53 Regulates Metabolic Genes [Pathway:R-CFA-71336] Pentose phosphate pathway
(precedingEvent)	[Reaction:R-CFA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ [Reaction:R-CFA-71296] PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphate
(inferredTo)	[Reaction:R-HSA-70377] G6PD multimers dehydrogenate G6P

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