Reactome | HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P

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HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P Show undefined attributes

catalystActivity	[CatalystActivity:70419] glucokinase activity of glucokinase and hexokinases [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9933515] RHEA:17826
dbId	70420
deleted	[Deleted:450107] Deletion of instance: 70114 [Deleted:622426] Deletion of instance: 500039 [Deleted:622430] Deletion of instance: 500039 [Deleted:450105] Deletion of instances: 70414, 70397, 70380
diseaseReaction	[FailedReaction:R-HSA-5621888] Defective HK1 does not phosphorylate Glc to form G6P - Homo sapiens [FailedReaction:R-HSA-5621918] Defective GCK does not phosphorylate Glc to form G6P - Homo sapiens
displayName	HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P
eventOf	[Pathway:R-HSA-70171] Glycolysis - Homo sapiens
followingEvent	[Reaction:R-HSA-8955760] PGM2L1:Mg2+ phosphorylates G6P to G1,6BP - Homo sapiens [Reaction:R-HSA-70471] GPI dimer isomerizes G6P - Homo sapiens [Reaction:R-HSA-70377] G6PD multimers dehydrogenate G6P - Homo sapiens [Reaction:R-HSA-9638127] PGM1:Mg2+ isomerises G6P to G1P - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-70113] Glc [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:199694] The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate [LiteratureReference:9820637] Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1 [LiteratureReference:199692] Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity [LiteratureReference:9828521] Hepatic HKDC1 Expression Contributes to Liver Metabolism [LiteratureReference:199700] Compartmentation of hexokinase in human blood cells. Characterization of soluble and particulate enzymes. [LiteratureReference:199710] Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants. [LiteratureReference:391483] Human liver glucokinase gene: cloning and sequence determination of two alternatively spliced cDNAs [LiteratureReference:264743] GLUT2 in pancreatic and extra-pancreatic gluco-detection (review) [LiteratureReference:9828532] Hexokinase domain-containing protein-1 in metabolic diseases and beyond
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP
orthologousEvent	[Reaction:R-MMU-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Mus musculus [Reaction:R-CFA-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Canis familiaris [Reaction:R-BTA-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Bos taurus [Reaction:R-SSC-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Sus scrofa [Reaction:R-DRE-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Danio rerio [Reaction:R-XTR-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Xenopus tropicalis [Reaction:R-GGA-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Gallus gallus [Reaction:R-DME-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Drosophila melanogaster [Reaction:R-CEL-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Caenorhabditis elegans [Reaction:R-SPO-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Schizosaccharomyces pombe [Reaction:R-SCE-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Saccharomyces cerevisiae [Reaction:R-PFA-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Plasmodium falciparum [Reaction:R-RNO-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Rattus norvegicus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-30537] G6P [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-211346] NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9820651] Hill, David P, 2022-11-18
revised	[InstanceEdit:450087] D'Eustachio, P, 2009-12-11 [InstanceEdit:9820650] D'Eustachio, Peter, 2022-11-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70420
summation	[Summation:391482] Cytosolic glucokinase and the three isoforms of hexokinase c...
updateTrackers	[UpdateTracker:9790504] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v33:[addLiteratureReference, modifyText] [UpdateTracker:9791584] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v28:[addLiteratureReference, add_removeSummation] [UpdateTracker:9791235] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v32:[addLiteratureReference, modifyText] [UpdateTracker:9792318] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v22:[addLiteratureReference] [UpdateTracker:9846610] Update Tracker - [Reaction:70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - v84:[addLiteratureReference, modifyText] [UpdateTracker:9777234] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v72:[addOutput]

Referrals

(precedingEvent)	[Reaction:R-HSA-8955760] PGM2L1:Mg2+ phosphorylates G6P to G1,6BP [Reaction:R-HSA-70471] GPI dimer isomerizes G6P [Reaction:R-HSA-70377] G6PD multimers dehydrogenate G6P [Reaction:R-HSA-9638127] PGM1:Mg2+ isomerises G6P to G1P
(hasEvent)	[Pathway:R-HSA-70171] Glycolysis
(normalReaction)	[FailedReaction:R-HSA-5621888] Defective HK1 does not phosphorylate Glc to form G6P [FailedReaction:R-HSA-5621918] Defective GCK does not phosphorylate Glc to form G6P
(replacementInstances)	[Deleted:450107] Deletion of instance: 70114 [Deleted:622426] Deletion of instance: 500039 [Deleted:622430] Deletion of instance: 500039 [Deleted:450105] Deletion of instances: 70414, 70397, 70380
(updatedInstance)	[UpdateTracker:9790504] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v33:[addLiteratureReference, modifyText] [UpdateTracker:9791584] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v28:[addLiteratureReference, add_removeSummation] [UpdateTracker:9791235] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v32:[addLiteratureReference, modifyText] [UpdateTracker:9792318] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v22:[addLiteratureReference] [UpdateTracker:9846610] Update Tracker - [Reaction:70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - v84:[addLiteratureReference, modifyText] [UpdateTracker:9777234] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v72:[addOutput]

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