G6PD multimers dehydrogenate G6P

Stable Identifier
R-HSA-70377
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+, D-glucose 6-phosphate + NADP(+) => 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH
ReviewStatus
5/5
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G6PD multimers dehydrogenate G6P
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Cytosolic glucose-6-phosphate dehydrogenase (G6PD) catalyzes the reaction of glucose 6-phosphate and NADP+ to form D-glucono-1,5-lactone 6-phosphate and NADPH + H+. This constitutes the first committed step of the pentose phosphate pathway and it is critical to the maintenance of NAPDH pool and redox homeostasis. For this reason, anti-cancer therapies are making this step as a prominent target in cancer therapy (Zhang et al. 2014). The reaction is inhibited by high ADP/AMP concentration, and by high NAPDH concentration. Biochemical studies indicate that both G6PD dimers and tetramers are catalytically active and present under physiological conditions in vivo (Au et al. 2000). Mutations that reduce the catalytic efficiency of G6PD are remarkably common in human populations; these appear to have a protective effect against malaria (e.g., Luzzatto and Afolayan 1968).
Literature References
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as an event of
Catalyst Activity

glucose-6-phosphate dehydrogenase activity of G6PD dimer and tetramer [cytosol]

Physical Entity
G6PD dimer and tetramer [cytosol] (Homo sapiens)
Activity
glucose-6-phosphate dehydrogenase activity (GO:0004345)
Orthologous Events
G6PD multimers dehydrogenate G6P (Bos taurus)
G6PD multimers dehydrogenate G6P (Caenorhabditis elegans)
G6PD multimers dehydrogenate G6P (Canis familiaris)
G6PD multimers dehydrogenate G6P (Dictyostelium discoideum)
G6PD multimers dehydrogenate G6P (Drosophila melanogaster)
G6PD multimers dehydrogenate G6P (Mus musculus)
G6PD multimers dehydrogenate G6P (Plasmodium falciparum)
G6PD multimers dehydrogenate G6P (Rattus norvegicus)
G6PD multimers dehydrogenate G6P (Saccharomyces cerevisiae)
G6PD multimers dehydrogenate G6P (Schizosaccharomyces pombe)
G6PD multimers dehydrogenate G6P (Sus scrofa)
G6PD multimers dehydrogenate G6P (Xenopus tropicalis)
Cross References
RHEA
Authored
D'Eustachio, P  (2003-06-25)
Reviewed
Inga, A  (2016-02-04)
Zaccara, S  (2016-02-04)
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