Reactome | Phosphorylation of Cdc25A at Ser-123 by Chk1

Schema > Reaction > Entries

Phosphorylation of Cdc25A at Ser-123 by Chk1 Show undefined attributes

catalystActivity	[CatalystActivity:10741321] protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
dbId	10741323
displayName	Phosphorylation of Cdc25A at Ser-123 by Chk1
eventOf	[Pathway:R-CEL-176187] Activation of ATR in response to replication stress - Caenorhabditis elegans [Pathway:R-CEL-69601] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A - Caenorhabditis elegans
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-69604] Phosphorylation of Cdc25A at Ser-123 by Chk1 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [DefinedSet:R-CEL-143487-5] Homologues of CDC25A [nucleoplasm]
isInDisease	false
isInferred	true
name	Phosphorylation of Cdc25A at Ser-123 by Chk1
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [DefinedSet:R-CEL-143488-5] Homologues of p-S124-CDC25A [nucleoplasm]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-69604
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-69601] Ubiquitin Mediated Degradation of Phosphorylated Cdc25A [Pathway:R-CEL-176187] Activation of ATR in response to replication stress
(inferredTo)	[Reaction:R-HSA-69604] Phosphorylation of Cdc25A at Ser-123 by Chk1

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