Reactome | CK2:FACT phosphorylates TP53

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CK2:FACT phosphorylates TP53 Show undefined attributes

catalystActivity	[CatalystActivity:10891638] protein serine/threonine kinase activity of CK2:FACT [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10891640
displayName	CK2:FACT phosphorylates TP53
eventOf	[Pathway:R-DME-6804756] Regulation of TP53 Activity through Phosphorylation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6805059] CK2:FACT phosphorylates TP53 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-DME-3222171] p-S15,S20-TP53 Tetramer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CK2:FACT phosphorylates TP53
output	4 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-DME-6805046] p-S15,S20,S392-TP53 Tetramer [nucleoplasm]
precedingEvent	[Reaction:R-DME-6805061] CK2 binds FACT - Drosophila melanogaster [Reaction:R-DME-6799246] CHEK1 phosphorylates TP53 - Drosophila melanogaster [Reaction:R-DME-69685] CHEK2 phosphorylates TP53 - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-6805059
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-6804756] Regulation of TP53 Activity through Phosphorylation
(inferredTo)	[Reaction:R-HSA-6805059] CK2:FACT phosphorylates TP53